New carotenoids fromStreptomyces mediolani n. sp.

Arcamone, F; Camerino, B.; Cotta, E.; Franceschi, Giovanni; Grein, A.; Penco, Susanna; Spalla, C.

doi:10.1007/bf02034366

Cited by 30 publications

(11 citation statements)

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“…From 27 a , crocetindial, 2,3,6‐trimethyibenzaldehyde, and 4‐acetoxy‐2,3,6‐trimethylbenzaldehyde and from 27 b , crocetindial and 4‐acetoxy‐2,3,6‐trimethylbenzaldehyde were obtained. The structures were confirmed by synthesis through a Wittig reaction of crocetindial and 2,3,6‐trimethyl‐4‐(2′‐tetrahydropyranyloxy)benzylphosphonium and/or 2,3,6‐trimethylbenzylphosphonium bromide followed by deprotection of the phenol groups 82. The compounds were of interest since some carotenoid derivatives, such as retinoic acid, possess antineoplastic properties…”

Section: New Antibioticsmentioning

confidence: 88%

Fifty Years of Chemical Research at Farmitalia

Arcamone¹

2009

Chemistry A European J

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This review contains a brief description of the chemistry developed in Farmitalia and, after 1978, Farmitalia-Carlo Erba Research Laboratories, during the second half of the last century. It gives an overview of work that represents a significant part of the chemistry carried out in Italy during this period in the field of medicinal and natural product chemistry. This is particularly true when we consider in addition to the work done intramurally in the said laboratories, the work done by academic scientists in the frame of the various extramural collaborations. Only a fraction of the chemical research actually carried out is reported here as time and space dictated a selection. Subjects typically associated with Farmitalia and which gave rise to important scientific or therapeutic outcomes are given preference in this review.

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Section: New Antibioticsmentioning

confidence: 88%

Fifty Years of Chemical Research at Farmitalia

Arcamone¹

2009

Chemistry A European J

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“…The importance of its effects is attracting great interest and is bringing an avalanche of investigators into every aspect of its chemistry, biochemistry and clinical medicine. Adriamycin and daunorubicin belong to the antracycline family of antibiotics (13)(14)(15). Antitumor action is presumed due to intercalation in DNA, thereby preventing replication.…”

Section: Nhmentioning

confidence: 99%

Direction of carbohydrate research in the near future

Whistler¹

1977

Pure and Applied Chemistry

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“…The esters were chromato graphed on silica-gel. Elution with benzene afforded 2- 7.63 (IH, d, J = 16 cps). VIII was hydrolyzed with 5~Ia ethanolic sodium hydroxide at room temperature to give the acid (XII), mp 168~169'C (unstable) from acetonitrile.…”

Section: ) Ethyl 2-cis4-trans-5-( Ji-cyclohexen-ji-yl )-3-l71ethyl-mentioning

confidence: 99%