New ceramide from the aerial part of <i>Tinospora oblongifolia</i> with cytotoxic activities

Samita, Fidelis Nekesa; Ochieng, Charles O.; Owuor, P.O.; Manguro, Lawrence A.O.

doi:10.1080/14786419.2014.895725

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Up to now, fifteen of this kind of ingredients have been isolated and identified. Among them, β -sitosterol and β -sitosteryl glucoside were frequently found in Tinospora species [ 110 , 113 , 139 , 144 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology

Chi

She

Han

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The genus Tinospora includes 34 species, in which several herbs were used as traditional medicines by indigenous groups throughout the tropical and subtropical parts of Asia, Africa, and Australia. The extensive literature survey revealed Tinospora species to be a group of important medicinal plants used for the ethnomedical treatment of colds, headaches, pharyngitis, fever, diarrhea, oral ulcer, diabetes, digestive disorder, and rheumatoid arthritis. Indian ethnopharmacological data points to the therapeutic potential of the T. cordifolia for the treatment of diabetic conditions. While Tinospora species are confusing in individual ingredients and their mechanisms of action, the ethnopharmacological history of those plants indicated that they exhibit antidiabetic, antioxidation, antitumor, anti-inflammation, antimicrobial, antiosteoporosis, and immunostimulation activities. While the clinical applications in modern medicine are lacking convincing evidence and support, this review is aimed at summarizing the current knowledge of the traditional uses, phytochemistry, biological activities, and toxicities of the genus Tinospora to reveal its therapeutic potentials and gaps, offering opportunities for future researches.

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Section: Chemical Constituentsmentioning

confidence: 99%

Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology

Chi

She

Han

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…Moreover, the molecular ion also yielded ions at m / z 585 [M − H + HCOOH − 2H 2 O] − and m / z 560 [M − H + HCOOH − H 2 O − CO − CH 3 ] − . By comparing with the literature data, compound 60 was tentatively identified as daucosterol [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Rapid Characterization and Identification of Non-Diterpenoid Constituents in Tinospora sinensis by HPLC-LTQ-Orbitrap MSn

Jiao

Zhang

et al. 2018

Molecules

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Tinospora sinensis, a kind of Chinese folk medicine, has functions of harmonizing qi and blood, dredging the channels and collaterals, calming and soothing the nerves. In the present study, a method based on high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (HPLC-LTQ-Orbitrap) was developed for the systematical characterization of the non-diterpenoid constituents which possessed remarkable biological activities in T. sinensis, like anti-tumor, anti-inflammatory, hypoglycemic activity and immunomodulatory activity. Based on the accurate mass measurement (<5 ppm), retention times and MS fragmentation ions, 60 non-diterpenoid constituents were unambiguously or tentatively characterized from T. sinensis extract, including 27 alkaloids, 23 phenylpropanoids, seven sesquiterpenoids and three other constituents. Among them, 13 compounds were tentatively identified as new compounds. Finally, three of the non-diterpenoid constituents were purified and identified, which further confirmed the validity of the results. This study demonstrated that the HPLC-LTQ-Orbitrap MSn platform was a useful and efficient analytical tool to screen and identify constituents in natural medicine.

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Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Assaf

Nafady

Allam

et al. 2017

Natural Product Research

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Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (H, C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC 33.25 μM in comparison with 5-fluorouracil IC 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).

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New ceramide from the aerial part of Tinospora oblongifolia with cytotoxic activities

Cited by 3 publications

References 13 publications

Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology

Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology

Rapid Characterization and Identification of Non-Diterpenoid Constituents in Tinospora sinensis by HPLC-LTQ-Orbitrap MSn

Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

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