New challenges in cholangiocarcinoma candidates for elective surgery: harnessing the microbiome dysbiosis

Re, Oriana Lo; López-López, Víctor; Balaguer-Román, Andrés; Martínez-Sánchez, María Antonia; Eshmuminov, Dilmurodjon; Llamoza-Torres, Camilo Julio; Miura, Kiyonori; Baroja‐Mazo, Alberto; Ramı́rez, Pablo; Robles‐Campos, Ricardo; Ramos‐Molina, Bruno

doi:10.1007/s00423-023-02867-8

Cited by 1 publication

(1 citation statement)

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“…The worldwide prevalence of BTC has consistently presented a considerable challenge to public health initiatives over an extended period . Biobanking is transitioning into a new epoch characterized by the prominence of big data, in the age of big data, biobanking plays a pivotal role in advancing predictive, preventive, and personalized The Streptococcaceae family, particularly some strains of Streptococcus, have been investigated for their potential role in carcinogenesis (Re et al, 2023). One hypothesis is that they may induce chronic inflammation, a known risk factor for cancer.…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis

Wang,

Qin

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundGrowing evidence has shown that gut microbiome composition is associated with Biliary tract cancer (BTC), but the causality remains unknown. This study aimed to explore the causal relationship between gut microbiota and BTC, conduct an appraisal of the gut microbiome’s utility in facilitating the early diagnosis of BTC.MethodsWe acquired the summary data for Genome-wide Association Studies (GWAS) pertaining to BTC (418 cases and 159,201 controls) from the Biobank Japan (BBJ) database. Additionally, the GWAS summary data relevant to gut microbiota (N = 18,340) were sourced from the MiBioGen consortium. The primary methodology employed for the analysis consisted of Inverse Variance Weighting (IVW). Evaluations for sensitivity were carried out through the utilization of multiple statistical techniques, encompassing Cochrane’s Q test, the MR-Egger intercept evaluation, the global test of MR-PRESSO, and a leave-one-out methodological analysis. Ultimately, a reverse Mendelian Randomization analysis was conducted to assess the potential for reciprocal causality.ResultsThe outcomes derived from IVW substantiated that the presence of Family Streptococcaceae (OR = 0.44, P = 0.034), Family Veillonellaceae (OR = 0.46, P = 0.018), and Genus Dorea (OR = 0.29, P = 0.041) exerted a protective influence against BTC. Conversely, Class Lentisphaeria (OR = 2.21, P = 0.017), Genus Lachnospiraceae FCS020 Group (OR = 2.30, P = 0.013), and Order Victivallales (OR = 2.21, P = 0.017) were associated with an adverse impact. To assess any reverse causal effect, we used BTC as the exposure and the gut microbiota as the outcome, and this analysis revealed associations between BTC and five different types of gut microbiota. The sensitivity analysis disclosed an absence of empirical indicators for either heterogeneity or pleiotropy.ConclusionThis investigation represents the inaugural identification of indicative data supporting either beneficial or detrimental causal relationships between gut microbiota and the risk of BTC, as determined through the utilization of MR methodologies. These outcomes could hold significance for the formulation of individualized therapeutic strategies aimed at BTC prevention and survival enhancement.

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Section: Discussionmentioning

confidence: 99%