New Challenges of Treatment for Locally Advanced Head and Neck Cancers in the Covid-19 Pandemic Era

Mireștean, Camil Ciprian; Crişan, Anda; Mitrea, Adina; Buzea, Călin Gheorghe; Iancu, Roxana Irina; Iancu, Dragoș Petru Teodor

doi:10.3390/jcm10040587

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…96 Repair of this DNA damage determines the radiotolerance of cancer cells. 97 The combination of IMRT and IGRT significantly reduces acute and late rectal toxicity (Figure 2). 98 Radiation therapy is an effective way to treat tumors, but the sensitivity of tumors to radiation varies greatly from patient to patient.…”

Section: Prostate Cancermentioning

confidence: 97%

Radiation induced therapeutic effects in cancerous and tumor cells: A review

Upadhyay¹,

Rai²

2023

JSRT

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Present review article describes use of radiation and radionuclides on cancer and cancer cell therapeutics. It also sketches out cumulative effects of radiation exposure received by the patients during cancer diagnostics. Though, in cancer therapeutics a selected and permissible dose is provided in several cycles to ablate the neoplastic cells and improve the condition of patient, but radiation harms surrounding cells and imparts negative effects on biology of cells. Ionizing radiation (IR) promotes cancer cell death through cytotoxicity. This article emphasizes both remedial effects and biological effects of radiation and radio-resistance in cells. It suggests safe use of radionucleides by encapsulating them in nanomaterials so as to use it alternate to chemotherapy to destroy various cancer types to enhance the survival of normal cells. This article explains effect of ionizing and non-ionizing radiation on cellular metabolism and genetics.

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Section: Prostate Cancermentioning

confidence: 97%

Radiation induced therapeutic effects in cancerous and tumor cells: A review

Upadhyay¹,

Rai²

2023

JSRT

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“…Several groups developed recommendations on the management of patients with head and neck cancer during the pandemic, including both general recommendations as well as specific surgical and non-surgical recommendations [16][17][18][19][20] . Treatment of head and neck cancer has been restricted around the world due to capacity limitations and to the increased risk of infection for both staff and patients.…”

Section: Type Of Treatmentmentioning

confidence: 99%

The impact of the Covid-19 pandemic on the management of head and neck cancer patients at a tertiary care institution in Poland: A case-control study

Szewczyk,

Pazdrowski,

Golusiński

et al. 2024

Preprint

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Objective: To assess the impact of the Covid-19 pandemic on the diagnosis and treatment of patients at tertiary hospital in Poland. Design, setting, participants: This was a retrospective review of head and neck cancer patients presented to the multidisciplinary tumour board (MTB) during the 12-month period from March 2020 through February 2021 and compared to patients presented to the MTB during the prior, pre-pandemic 12-month period from February 2019 to March 2020. Main outcomes and measures: Patient demographic and clinical variables were compared: sex; age at diagnosis; distance from hospital; date of first visit, radiological diagnosis, pathology specimen, MTB meeting, and initiation of primary and adjuvant treatment Results: The number of patients presented to the MTB increased by 22% (278 to 340) from the pre-pandemic to the pandemic period. The mean time from MTB presentation to treatment initiation increased significantly from 17.1 to 21.7 days. The mean time from first visit to treatment start increased from 44.7 to 54.4 days. The proportion of patients with early-stage oropharyngeal cancer who underwent primary surgery rose from 47.3% to 86.6%. The percentage of patients who received palliative radiotherapy increased from 20.5% to 32.9%. The proportion of patients who received best supportive care rose from 1.8% to 6.2%. Conclusion: One of the most notable findings of this study was the increased time from first visit to treatment initiation, which could negatively impact patient outcomes. The differences in the treatment received in these two periods should be further evaluated to determine their influence on survival

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“…Several groups developed recommendations on the management of patients with head and neck cancer during the pandemic, including general recommendations as well as specific surgical and non-surgical recommendations [16][17][18][19][20]. Treatment of head and neck cancer has been restricted around the world due to capacity limitations and to the increased risk of infection for both staff and patients.…”

Section: Type Of Treatmentmentioning

confidence: 99%

The impact of the COVID-19 pandemic on the management of head and neck cancer patients at a tertiary care institution in Poland

Szewczyk¹,

Pazdrowski²,

Golusiński³

et al. 2021

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Aim of the study: To assess the impact of the COVID-19 pandemic on the diagnosis and treatment of patients at a tertiary hospital in Poland. Material and methods: This was a retrospective review of head and neck cancer patients who presented to the multidisciplinary tumour board (MTB) during the 12-month period from March 2020 to February 2021 and compared to patients who presented to the MTB during the prior, pre-pandemic 12-month period from February 2019 to March 2020: Patient demographic and clinical variables were compared: sex, age at diagnosis, distance from hospital, date of first visit, radiological diagnosis, pathology specimen, MTB meeting, and initiation of primary and adjuvant treatment Results: The number of patients who presented to the MTB increased by 22% (278 to 340) from the pre-pandemic to the pandemic period. The mean time from MTB presentation to treatment initiation increased significantly from 17.1 to 21.7 days. The mean time from first visit to treatment start increased from 44.7 to 54.4 days. The proportion of patients with early-stage oropharyngeal cancer who underwent primary surgery rose from 47.3% to 86.6%. The percentage of patients who received palliative radiotherapy increased from 20.5% to 32.9%. The proportion of patients who received best supportive care rose from 1.8% to 6.2%. Conclusions: One of the most notable findings of this study was the increased time from first visit to treatment initiation, which could negatively impact patient outcomes. The differences in the treatment received in these two periods should be further evaluated to determine their influence on survival.

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New Challenges of Treatment for Locally Advanced Head and Neck Cancers in the Covid-19 Pandemic Era

Cited by 5 publications

References 63 publications

Radiation induced therapeutic effects in cancerous and tumor cells: A review

Radiation induced therapeutic effects in cancerous and tumor cells: A review

The impact of the Covid-19 pandemic on the management of head and neck cancer patients at a tertiary care institution in Poland: A case-control study

The impact of the COVID-19 pandemic on the management of head and neck cancer patients at a tertiary care institution in Poland

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