New chiral phosphinite ligands with C₂‐symmetric axis and their possible applications in Ru‐catalyzed asymmetric transfer hydrogenation

Abstract

Following activation by NaOH, these chiral ruthenium complexes serve as catalyst precursors for the asymmetric transfer hydrogenation of acetophenone derivatives in iPrOH. The complexes 3 and 4 showed high catalytic activity but low selectivity in asymmetric transfer hydrogenation reactions.

New iminophosphine–Ru(II) complexes and their application in hydrogenation and transfer hydrogenation

“…It is known that the catalytic efficiency of hemilabile phosphine derivative PN ligands increases in the catalytic reactions of Ru(II) complexes. This is because in complex structures the soft ruthenium metal coordinates with the soft phosphorus and the hard nitrogen acts as an efficient catalyst …”

“…This is because in complex structures the soft ruthenium metal coordinates with the soft phosphorus and the hard nitrogen acts as an efficient catalyst. [13][14][15] In this article, we report the synthesis of Ru(II) complexes with iminophosphines. These complexes were used as catalysts in the reduction of derivatives of styrenes and ketones in homogeneous catalysis.…”

Novel cyclohexyl‐based aminophosphine ligands and use of their Ru(II) complexes in transfer hydrogenation of ketones

“…Recently, we reported that the novel half‐sandwich complexes, based on ligands with PN and PO backbone, are active catalysts in the reduction of aromatic ketones . The observed activity of these complexes has encouraged us to examine other analogous ligands and their ruthenium complexes.…”

Asymmetric transfer hydrogenation of acetophenone derivatives with novel chiral phosphinite based η6-p-cymene/ruthenium(II) catalysts

“…Recently, we reported the synthesis of new P,O-ligands [21,22] and their application in ruthenium-catalyzed transfer hydrogenation reactions [23e25]. As an extension of the ongoing research program, we become interested in the synthesis of new unsymmetric ligands: (2R)-2-[benzyl{(2-((diphenylphosphanyl)oxy)ethyl)}amino] butyldiphenylphosphinite, 1 and (2R)-2-[benzyl{(2-((dicyclohexylphosphanyl)oxy)ethyl)}amino]butyldicyclohexylphosphinite, 2.…”