New chitosan derivatives for the preparation of rokitamycin loaded microspheres designed for ocular or nasal administration

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

“…[11][12][13][14][15][16] The existence of direct pathways from the nasal cavity to the central nervous system (CNS) raises the possibility that intranasal drug administration may limit systemic exposure, and/or allow therapeutics that cannot penetrate the blood-brain barrier (BBB) to be rapidly targeted to the CNS using olfactory and trigeminal neural pathways. [17][18][19] For example, zidovudine, 20 local anestetics, 21,22 antihistamines, 23,24 dopamine, 25 and neuropeptides 26 appear to be transported from the nasal cavity to the CNS.…”

“…RK encapsulation into CH microspheres increases its poor ex vivo permeability through nasal sheep mucosa. 12 On the basis of the above-mentioned results, the purpose of the present work was the preparation of microspheres based on CH salt, chitosan glutamate (CG), by using the parameters previously set to obtain microparticles suitable for nasal administration. 12,53 Furthermore, the mucoadhesive properties of microspheres prepared were investigated, and the influence of CG on the in vivo RK absorption, after nasal administration, was evaluated.…”

“…12 On the basis of the above-mentioned results, the purpose of the present work was the preparation of microspheres based on CH salt, chitosan glutamate (CG), by using the parameters previously set to obtain microparticles suitable for nasal administration. 12,53 Furthermore, the mucoadhesive properties of microspheres prepared were investigated, and the influence of CG on the in vivo RK absorption, after nasal administration, was evaluated. In particular, the different transport pathways of drug through respiratory or olfactory region of the nose were investigated by quantifying the RK amount in the blood and in the CSF.…”

“…A comparison of the performances of new formulations with microparticles, based on CH previously studied and drug itself, was carried out. 12,53 As controls, nasal administration of RK aqueous suspensions and intravenous (IV) administration of a RK solution were performed. No comparisons were made with the direct nasal administration of solid pure drug, owing the very low dose (about 300 :g).…”

Controlled Release of Drugs for Management of Pulpitis

“…Synthetic or natural polymers are used for the preparation of microspheres for nasal, respiratory, oral or intravenous administration (43)(44)(45). Natural polymers such as collagen, chitosan, hyaluronic acid, alginate and cellulose have been used for production of microspheres due to their optimal biocompatibility.…”