New chlamydosporol derivatives from the endophytic fungus Pleosporales sp. Sigrf05 and their cytotoxic and antimicrobial activities

Lai, Daowan; Mao, Ziling; Zhou, Zijiang; Zhao, Siji; Xue, Mengyao; Dai, Jungui; Zhou, Ligang; Li, Dianpeng

doi:10.1038/s41598-020-65148-0

Cited by 16 publications

(10 citation statements)

References 24 publications

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“…Sigrf05, residing inside the tuberous roots of Siraitia grosvenorii. Compound 109 exhibited weak inhibition against Agrobacterium tumefaciens, B. subtilis, R. solanacearum, and X. vesicatoria with the same MIC value of 100.0 µM [65]. Compound 111 also exhibited moderate inhibition against S. aureus ATCC 29213 and ATCC 700699 with MICs of 25 and 50 µM, respectively [66].…”

Section: Minor Taxa Of the Ascomycetesmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Minor Taxa Of the Ascomycetesmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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“…(2017) PC-3 1.09 μM HCT-116 2.31 μM Phomone E (12) HL-60 1.04 μM PC-3 5.90 μM HCT-116 9.84 μM Pleospyrone A (13) HepG2 5.07 μM Pleosporales sp. Sigrf05 Siraitia grosvenorii (T) China Lai et al. (2020) BGC-823 1.26 μM NCI–H1650 15.1 μM Daoy 2.72 μM Pleospyrone D (14) NCI–H1650 29.6 μM Pleospyrone E (15) HCT-116 1.17 μM HepG2 20.3 μM BGC-823 20.7 μM NCI–H1650 6.26 μM Daoy 19.9 μM Rhizopycnin C (16) A-549 25.5 μM Rhizopycnis vagum Nitaf22 Nicotiana tabacum (T) China Lai et al.…”

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

“…Pleospyrone A and Pleospyrone E were cytotoxic against HepG2, BGC-823 (gastric cancer), NCI–H1650 (non-small-cell lung carcinoma) and DAOY (medulloblastoma) cell lines in the range of 1.26–20.7 μM of IC 50 values, while Pleospyrone D was active against only NCI–H1650 with IC 50 of 29.6 μM. Pleospyrone E also possess cytotoxicity against HCT-116 cancer cell line with 1.17 μM of IC 50 value, while other compounds remain inactive ( Lai et al., 2020 ). An unprecedented dibenzo-α-pyrone, Rhizopycnin C (16) was separated from culture of endophytic fungus Rhizopycnis vagum Nitaf22 harbored in Nicotiana tabacum .…”

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

Endophytic fungi: A treasure trove of novel anticancer compounds

Prajapati

Goswami

Rawal

2021

Current Research in Pharmacology and Drug Discovery

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Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Henceforth, there is undeniably an inflated necessity for safe, promising, and less harmful new anticancer drugs. Natural compounds from various sources like plants, animals, and microorganisms have occupied a center stage in drug discovery due to their tremendous chemical diversity and potential as therapeutic agents. Endophytic microbes are symbiotically associated with plants and have been proven to produce novel or analogues of host bioactive metabolites exhibiting a variety of biological activities including anticancer activity. This review emphasizes on structurally diverse unprecedented anticancer natural compounds that have been reported exclusively from endophytic fungi from 2016 to 2020. It covers chemical nature of metabolites, its fungal source associated with terrestrial, as well as marine plants and anticancer activity based on their cytotoxicity profile against various cancer cell lines. Many of these fungal metabolites with promising anticancer activity can be used as lead molecules for in silico experiments and deserve special attention from scientists for further in vitro and clinical research.

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“…The B3LYP/6-31 G(d)-optimized conformer of (5R)-11 was used to calculate the optical rotation. The calculation was carried out using the time-dependent DFT method at the B3LYP/6-31+G(d,p) level (PCM = MeOH), as described previously (Lai et al, 2020).…”

Section: Optical Rotation Calculationmentioning

confidence: 99%

Eremophilane-Type Sesquiterpenoids From the Endophytic Fungus Rhizopycnis vagum and Their Antibacterial, Cytotoxic, and Phytotoxic Activities

et al. 2020

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Fourteen new eremophilane-type sesquiterpenoids, named rhizoperemophilanes A∼N (1∼14), together with eight known congeners, were isolated from the culture of the endophytic fungus Rhizopycnis vagum. The structures of the new compounds were elucidated by extensive spectroscopic analyses, as well as ECD calculations and the modified Mosher's method for the assignment of the absolute configurations. Rhizoperemophilane J (10) contains an uncommon C-4/C-11 epoxy ring, while rhizoperemophilane N (14) features an unprecedented 3-nor-eremophilane lactone-lactam skeleton. These metabolites were evaluated for their antibacterial, cytotoxic, and phytotoxic activities. Among them, compounds 11, 16, and 20 displayed antibacterial activities, while 14 showed selective cytotoxicity against NCI-H1650 and BGC823 tumor cells. Moreover, compounds 5, 6, 12, 13, 16, and 19 exhibited strong phytotoxic activities against the radicle elongation of rice seedlings.

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New chlamydosporol derivatives from the endophytic fungus Pleosporales sp. Sigrf05 and their cytotoxic and antimicrobial activities

Cited by 16 publications

References 24 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Endophytic fungi: A treasure trove of novel anticancer compounds

Eremophilane-Type Sesquiterpenoids From the Endophytic Fungus Rhizopycnis vagum and Their Antibacterial, Cytotoxic, and Phytotoxic Activities

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