New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A

Lipid–Drug Conjugate for Enhancing Drug Delivery

“…40,44–46 Similarly, an adjacent disulfide bond may also facilitate cleavage. 47 Some spacers or linkers are also used in the preparation of conjugates. Those spacers or linkers not only facilitate the formation of conjugates between two molecules without compatible functional groups but also affect ester hydrolysis.…”

Stereochemistry and complete 1H and 13C NMR signal assignment of C‐20‐oxime derivatives of posterone 2,3‐acetonide in solution state

“…Functionalization of self-assembly inducer squalene and the preparation of its coupled derivatives 4 and 5 attached to a linker moiety were prepared following previously published procedures. [12] A 34.2 mg (0.0819 mmol) of ecdysteroid substrate 2 was dissolved in 6 ml of anhydrous dichloromethane in a two-neck round-bottom flask. The 1.5 equivalents of the disulfide bridge containing compound 4 (74.6 mg, 0.1229 mmol) or Substrate 5 (70.2 mg, 0.1229 mmol) were added dropwise under stirring.…”

Exploitation of amaranth oil fractions enriched in squalene for dual delivery of hydrophilic and lipophilic actives

“…Usually, in the treatment of various diseases it is not sufficient to use highly active drugs, the effectiveness of any active being mainly dependent upon its delivery in an appropriate concentration to target cells and tissue (Borrelli et al, 2014). A great challenge comes from the difficulty to design functional delivery systems which combine low toxicity, lack of immunogenicity and biodegradability, does not accumulate in cells or tissues, and could also bring supplementary biological effects (Jyoti et al, 2015;Lacatusu et al, 2012).…”