New clinical criteria for the assessment of liver involvement in Hodgkin's disease

Gobbi, Paolo G.; Parrinello, Giuseppe Attardo; Prisco, Ubaldo Di; Fédérico, Massimo; Bonacorsi, Goretta; Dini, Daniele; Marabelli, S.; Rizzo, Salvatore; Ascari, E

doi:10.1016/0277-5379(82)90125-0

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…The study by Gobbi et al. on 133 patients who underwent laparotomy and laparoscopy showed that liver involvement was not associated with gender or histologic type but was associated with the presence of B symptoms 25 . In contrast, the retrospective study by Bach et al.…”

Section: Resultsmentioning

confidence: 96%

“…It has evolved and has been updated and modified over the last decades due to improvements in radiographic staging, but, unfortunately, it has not provided a clear definition of liver involvement. Only a few published studies report their definition of liver involvement as shown in this review 24,25 . Different diagnostic tools, outcome definition, and interpretation of liver involvement in the included studies make it impossible to compare outcomes between studies.…”

Section: Discussionmentioning

confidence: 99%

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Liver involvement in pediatric Hodgkin lymphoma: A systematic review by an international collaboration on Staging Evaluation and Response Criteria Harmonization (SEARCH) for Children, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL)

Hagleitner

Metzger

Flerlage

et al. 2020

Pediatric Blood & Cancer

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Hepatic involvement in Hodgkin lymphoma (HL) is uncommon (∼5% of patients) but always implies stage IV disease. Accurate staging is mandatory for making the appropriate risk assignment and treatment decisions. The Staging Evaluation and Response Criteria Harmonization for Childhood, Adolescent and Young Adult Hodgkin Lymphoma (SEARCH for CAYAHL) international working group conducted a systematic literature review of liver involvement in HL patients with the aim to propose a universally acceptable definition for liver involvement in pediatric HL. Thirty‐three articles describing 6985 pediatric and adult HL patients were reviewed, of which 539 (7.7%) mentioned liver involvement. The literature did not provide a uniform definition of hepatic involvement and we propose consensus criteria derived from the EuroNet and Children's Oncology Group protocols, where liver involvement is defined as any hepatic lesion on computed tomography scan that correlates with 18F‐FDG uptake greater than background liver. A clear definition of liver lesions is necessary to consistently identify liver involvement and compare its impact on outcomes among protocols worldwide.

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Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Liver involvement in pediatric Hodgkin lymphoma: A systematic review by an international collaboration on Staging Evaluation and Response Criteria Harmonization (SEARCH) for Children, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL)

Hagleitner

Metzger

Flerlage

et al. 2020

Pediatric Blood & Cancer

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“…Some clinical parameters found to be related to LI were: liver and/or spleen enlargement, elevated bromosulfophthalein (BSP) retention at 45 min, elevated aspartate aminotransferase (S-GOT), elevated serum alkaline phosphatase (SAP), positive lymphography and liver isotopic scan. Gobbi et al [14] showed that it is possible to obtain a high rate of correct diagnoses (89.5%) by using reliable clinical criteria. The available number of patients was small (133 patients with HD, 20 of them with LI), so that this result is uncertain.…”

Section: Introductionmentioning

confidence: 98%

“…Efforts have been made to identify clinical or laboratory features associated with LI [4,14]. Some clinical parameters found to be related to LI were: liver and/or spleen enlargement, elevated bromosulfophthalein (BSP) retention at 45 min, elevated aspartate aminotransferase (S-GOT), elevated serum alkaline phosphatase (SAP), positive lymphography and liver isotopic scan.…”

Section: Introductionmentioning

confidence: 99%

How to restrict liver biopsy to high-risk patients in early-stage Hodgkin's disease

Lieberz

Sextro

Paulus

et al. 2000

Annals of Hematology

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Liver biopsy is an invasive diagnostic method for detecting liver involvement (LI) in Hodgkin's disease (HD). The aim of this retrospective study was to determine and evaluate a method for restricting liver biopsy to a subset of patients. Between 1988 and 1994, a total of 2,016 patients with HD were treated within the HD4-6 study protocol of the German Hodgkin's Lymphoma Study Group (GHSG). We investigated the predictive power of abdominal ultrasound (US) and computed tomography (CT), as well as of various clinical factors related to LI, using univariate and multivariate methods. LI occurred in 4.9% of all patients (99/2,016) and in 3.0% of those who, if LI were disregarded, would have been included in clinical stages I and II. In multivariate analysis the presence of LI was significantly associated with splenic involvement or infradiaphragmatic involvement, absence of mediastinal involvement, serum alkaline phosphatase (SAP) level over 230 units/l, and age over 40 years. We used these factors to define a risk score for LI. LI is very rare in patients who would otherwise be in clinical stages I or II, but knowledge of LI is important because it has therapeutic consequences. With our risk score, liver biopsy is indicated for approximately one quarter of these patients otherwise in clinical stages I or II.

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“…The so-called B-symptomatology (occurrence of weight loss, fever, night sweats) is mostly present when the liver is involved. (33) Laboratory investigation reveals highly pathological "inflammatory criteria", which probably point to a consuming or malignant process. Alkaline phosphatase and bilirubin rise in the further course of disease (in about 80% of cases).…”

Section: Unclassifiable Form 1؊5%mentioning

confidence: 99%

Systemic diseases and the liver

Hepatology Principles and Practice

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New clinical criteria for the assessment of liver involvement in Hodgkin's disease

Cited by 10 publications

References 13 publications

Liver involvement in pediatric Hodgkin lymphoma: A systematic review by an international collaboration on Staging Evaluation and Response Criteria Harmonization (SEARCH) for Children, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL)

Liver involvement in pediatric Hodgkin lymphoma: A systematic review by an international collaboration on Staging Evaluation and Response Criteria Harmonization (SEARCH) for Children, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL)

How to restrict liver biopsy to high-risk patients in early-stage Hodgkin's disease

Systemic diseases and the liver

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