New Clinical Strain of<i>Neisseria gonorrhoeae</i>with Decreased Susceptibility to Ceftriaxone, Japan

Deguchi, Takashi; Yasuda, Mitsuru; Hatazaki, Kyoko; Kameyama, Koji; Horie, Kengo; Kato, Taku; Mizutani, Kohsuke; Seike, Kensaku; Tsuchiya, Tomohiro; Yokoi, Shigeaki; Nakano, Masahiro; Yoh, Mutsumasa

doi:10.3201/eid2201.150868

Cited by 68 publications

(30 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FC428 belonged to MLST sequence type 1903 (ST1903) and NG-MAST ST3435, which differ from the previously described ceftriaxone-resistant gonococcal strains (4)(5)(6)(7)(8). For example, MLST ST1903 differs by two and three loci from ST7363 and ST1901, respectively (Table 1).…”

mentioning

confidence: 99%

“…Four different ceftriaxone-resistant N. gonorrhoeae strains previously isolated in Japan (H041 [4] and GU140106 [5]), France (6) and Spain (F89 [7]), and Australia (A8806 [8]) have been characterized in detail. None of these strains have spread widely nationally or internationally.…”

mentioning

confidence: 99%

“…The penA allele of FC428 (penA FC428 ) was sequenced as previously described (13) to investigate the relatedness with the penA alleles of the previously reported ceftriaxone-resistant gonococcal strains (H041, GU140106, F89, and A8806 [4][5][6][7][8]). The deduced amino acid sequence of PBP 2 in FC428 elucidated a shared trait with the ceftriaxone-resistant strains GU140106 (5) and A8806 (8).…”

mentioning

confidence: 99%

See 2 more Smart Citations

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan

Nakayama

Shimuta

Furubayashi³

et al. 2016

Antimicrob Agents Chemother

163

144

View full text Add to dashboard Cite

We have characterized in detail a new ceftriaxone-and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3=-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan

Nakayama

Shimuta

Furubayashi³

et al. 2016

Antimicrob Agents Chemother

163

144

View full text Add to dashboard Cite

show abstract

“…However, these agents are no longer used to treat gonorrhea because of increases in the numbers of clinical strains exhibiting resistance to them (3). Although ceftriaxone monotherapy has been recommended as another first-line treatment (4), some clinical strains of N. gonorrhoeae exhibiting decreased susceptibility to ceftriaxone have already emerged (5,6). Currently, we cannot expect the rapid development of promising new agents to treat gonorrhea caused by antimicrobial-resistant N. gonorrhoeae strains; therefore, it is necessary to manipulate existing agents to enhance their efficacy toward gonorrhea and prevent the emergence and spread of antimicrobial-resistant N. gonorrhoeae strains.…”

mentioning

confidence: 99%

Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis

Soda

Ito

Matsumaru

et al. 2018

Antimicrob Agents Chemother

Self Cite

View full text Add to dashboard Cite

The objective of this study was to analyze the relationship between the pharmacokinetic (PK)/pharmacodynamic (PD) parameters of a single 2-g dose of extended-release formulation of azithromycin (AZM-SR) and its microbiological efficacy against gonococcal urethritis. Fifty male patients with gonococcal urethritis were enrolled in this study. In 36 patients, the plasma AZM concentrations were measured using liquid chromatography-tandem mass spectrometry, the AZM MIC values for the isolates were determined, and the microbiological outcomes were assessed. AZM-SR monotherapy eradicated in 30 (83%) of the 36 patients. AZM MICs ranged from 0.03 to 2 mg/liter. The mean value of the area under the concentration-time curve (AUC), estimated by population PK analysis using a two-compartment model, was 20.8 mg · h/liter. Logistic regression analysis showed that the PK/PD target value required to predict an eradication rate of ≥95% was a calculated AUC/MIC of ≥59.5. The AUC/MIC value was significantly higher in patients who achieved microbiological cure than in patients who achieved microbiological failure. Monte Carlo simulation using this MIC distribution revealed that the probability that AZM-SR monotherapy would produce an AUC/MIC exceeding the AUC/MIC target of 59.5 was 47%. Furthermore, the MIC distribution for strains isolated in this study was mostly consistent with that for strains currently circulating in Japan. In conclusion, in Japan, AZM-SR monotherapy may not be effective against gonococcal urethritis. Therefore, use of a single 2-g dose of AZM-SR either with or without other antibiotics could be an option to treat gonococcal urethritis if patients are allergic to ceftriaxone and spectinomycin or are diagnosed to be infected with an AZM-sensitive strain.

show abstract

“…In the same issue of Emerging Infectious Diseases, Deguchi et al described a case of multidrug-resistant N . gonorrhoeae ( 4 ), further highlighting the urgency for the innovative approach of using molecular tests to individualize treatment regimens. An ongoing study supported by the National Institutes of Health (R21AI109005) is evaluating how a laboratory-developed molecular N .…”

mentioning

confidence: 99%

Technological Solutions to Address Drug-ResistantNeisseria gonorrhoeae

Bristow¹,

Dong²,

Klausner³

2016

Emerg. Infect. Dis.

View full text Add to dashboard Cite

New Clinical Strain ofNeisseria gonorrhoeaewith Decreased Susceptibility to Ceftriaxone, Japan

Cited by 68 publications

References 9 publications

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan

Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis

Technological Solutions to Address Drug-ResistantNeisseria gonorrhoeae

Contact Info

Product

Resources

About