Herein, novel neural network (NN) methods that improve prediction accuracy and reduce output variance of the optimized input in the gradient method for cross‐sectional data are proposed, and the variability evaluation approach of optimized inputs in the semiconductor process is suggested. Specifically, electrical parameter measurements (EPMs) and power‐delay product of industrial high‐k metal gate DRAM peripheral 29‐stage ring oscillator circuits, including NMOS, PMOS, and interconnects, are focused on. The proposed methods find an optimized input to achieve a lower NN output variance in the gradient descent than one multilayer perceptron (MLP) and mean ensemble of MLPs even when considering the variabilities of the devices and interconnects. The local optima problem of one MLP is resolved by utilizing multiple MLPs trained with different train/validation data, their trimmed mean, and an additional learnable layer. Moreover, adding the learnable layer secures versatility for various parametric datasets. The methods improve the prediction accuracy (R2) by 5.6–15.6% in sparse data space compared to one MLP and the mean ensemble, decrease the NN output variance of the optimized input by 73.0–81.6% compared to one MLP and the mean ensemble, and are successfully verified by implementing it on EPMs of 3977 test patterns of 314 wafers and 16 lots.