New Combination of Triamcinolone, 5-Fluorouracil, and Pulsed-Dye Laser for Treatment of Keloid and Hypertrophic Scars

Asilian, Ali; Darougheh, Afshin; Shariati, F.

doi:10.1097/00042728-200607000-00007

Cited by 29 publications

(56 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Imiquimod 5% cream, a topical immune-response modifier, is approved for the treatment of genital warts, basal cell carcinoma and actinic keratoses (99). Imiquimod stimulates interferon, a proinflammatory cytokine, which increases collagen breakdown.…”

Section: Emerging Prophylactic Approachesmentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,178

1,012

View full text Add to dashboard Cite

Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

show abstract

Section: Emerging Prophylactic Approachesmentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,178

1,012

View full text Add to dashboard Cite

show abstract

“…Corticosteroids reduce excessive scarring by decreasing collagen synthesis, 36 and can inhibit fibroblast proliferation and encourage scar regression. 37 The efficacy of corticosteroid injections as first-or second-line therapy in KD is well established [38][39][40] ; however, there is a lack of level-one evidence from randomized trials. 18 Additionally, the effectiveness of single or multiple intralesional steroid injections is variable, with recurrence rates ranging from 9% to 50%.…”

Section: Intralesional Steroid Injectionsmentioning

confidence: 99%

Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature

Uddin

Bayat

2013

Br J Dermatol

View full text Add to dashboard Cite

SummaryKeloid disease (KD) is a common, benign, dermal fibroproliferative growth of unknown aetiology. Lesions tend to grow over time; they often recur following therapy and do not regress spontaneously. KD causes considerable discomfort due to pain, pruritus and inflammation, and a significant psychosocial impact with reduced quality of life. It is unique to humans and occurrence is higher in individuals with dark, pigmented, ethnic skin. There is a strong familial heritability, with a high ethnic predisposition in individuals of African, Asian and Hispanic descent. High recurrence rates and unknown resolution rates present a major problem for both the patient and clinician. Many treatment modalities exist; however, there is no single advocated therapy. Therefore, the aim of this review was to explore the most current literature regarding the range of treatment options for KD and to offer a structured approach in the management of KD, based on evidence and experience, to aid clinicians in their current practice. A focused history involving careful evaluation of the patient's symptoms, signs, quality of life and psychosocial well-being should direct targeted therapy, complemented with regular follow-up and re-evaluation. Many treatment modalities, such as intralesional steroid injection, silicone gel application, cryotherapy, lasers, 5-fluorouracil and, relatively recently, photodynamic therapy, are currently being used in clinical practice for the management of KD. Combination therapies have also been shown to be beneficial. However, there is a lack of robust, randomized, level-one, evidence-controlled trials evaluating these treatment options. Management of KD in ethnic pigmented skin remains a clinical challenge. Thus, a strategic approach with structured assessment, targeted therapy and focus on prevention of recurrence is highly recommended. Quality evidence is essential in order to tailor treatment effectively for the ethnic patient presenting with KD.What's already known about this topic?• Keloid disease (KD) is a common, benign, fibroproliferative tumour of unknown origin.• With high recurrence rates, treatment of KD remains a challenge for both the patient and clinician.• With lack of level-one evidence, there is no single advocated therapy.What does this study add?• A structured strategic approach for management of KD by utilizing a focused history, targeted therapy and regular follow-up of the patient.• Patients' symptoms, signs, quality of life and psychosocial well-being should be carefully evaluated and managed.

show abstract

“…In a study by Asilian et al found that the use of steroids in combination with 5-fluorouracil and pulsed-dye laser reduced hypertrophic scars and keloids formation. 11 In a prospective study of 121 keloid patients, managed in two teaching hospitals in Nigeria by Olaitan et al 12 found out that the symptoms associated with keloids include cosmesis 100.0%, itching 28.9%, pain 26.4%, burning sensation 19.3% and foul smell 3.3% respectively.…”

Section: Discussionmentioning

confidence: 99%

Management of Earlobe Keloids in Lokoja, Nigeria: A review of twelve cases

Iosr¹,

Ogah²

2014

IOSRJDMS

View full text Add to dashboard Cite

New Combination of Triamcinolone, 5-Fluorouracil, and Pulsed-Dye Laser for Treatment of Keloid and Hypertrophic Scars

Cited by 29 publications

References 22 publications

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature

Management of Earlobe Keloids in Lokoja, Nigeria: A review of twelve cases

Contact Info

Product

Resources

About