New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers

Kassym, Laura; Nounou, Mohamed Ismail; Zhumadilova, Z. K.; Dajani, Asad Izziddin; Barkibayeva, Nurgul; Myssayev, Ayan; Rakhypbekov, Tolebay; Abu-Hammour, A

doi:10.4103/1319-3767.187607

Cited by 8 publications

(17 citation statements)

References 29 publications

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“…In individuals whose spleen dimensions were high, the spleen stiffness values were higher but this did not show statistically any significant difference. Similar to this study there are also other studies reporting that did not detect any relation between spleen stiffness and dimensions 8,11,15,16 . In their studies, Guiffré et al reported that they looked at the average spleen stiffness according to the spleen bipolar diameter and spleen area.…”

Section: Discussionsupporting

confidence: 91%

“…Unlike this study, these two studies detected slightly higher values in men compared to women but statistically, this was not found meaningful. Yet, Kassym et al, by using ARFI in their study that they evaluated the relation between the rate of the spleen stiffness values of healthy individuals and their age, gender, spleen dimensions, ethnicity and obesity, similar to this study, they determined that the spleen stiffness was higher in women than men but differently from this study, these higher values were found statistically meaningful 15 . It was estimated that this difference resulted from the number of the population which was more than this study population.…”

Section: Discussionsupporting

confidence: 54%

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Sağlıklı Bireylerde Dalak Sertliğinin Point Shear Wave Elastografi ile Değerlendirilmesi

Özdemir

Can

Yilmaz

et al. 2022

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

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Aim: Sonoelastography is a non-invasive imaging method used to evaluate the mechanical properties of any tissue. The clinical value of method, the usage of which is increasingly prevailing, is gradually increasing and on account of having newly entered the application field, it is becoming a potential in the research area. Shear wave (SW) propagates faster in stiffer and lower elastic tissues. Studies on liver fibrosis musculoskeletal, breast, prostate, testis, and thyroid nodules accept this principle. In this study, aimed to determine the average values using the point shear wave elastography (pSWE) technique in normal healthy individuals and to determine the relationship of these values with age, gender, body mass index (BMI), and the spleen dimensions.Method: In 2019, patients who had visited the internal medicine service and those who have been directed to this clinics for grayscale ultrasound (US) for various reasons are voluntarily included in the study. The research was carried out consecutively on the same day by two specialist doctors who had 10 and 15 years of experience in ultrasonography and 3-year experience in elastography.Results: 39 (39%) of the 100 patients who participated in the study were men, and 61 (61%) were women. And the ages varied between 32-75 years (y) (54,5±9,5). The average spleen stiffness was found to be 89,2±43,3 kilopascal (kPa) (14,2-152,3) by the first observer and 89,4±41,1 kPa (14,4-151,1) by the second observer.Conclusion: To facilitate the common clinical usage and to evaluate the change in the stiffness of the spleen in different patients, first of all, it is required to determine the normal values of the stiffness of the spleen in healthy individuals using sonoelastography. In this study, the average spleen parenchyma stiffness was detected as higher than in previous studies. The values obtained in this study can be used to function as a comparison to determine the spleen stiffness. They can be used as referential to examine the different spleen pathologies in the clinical environments that use Esaote myLab device and pSWE method.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 54%

Sağlıklı Bireylerde Dalak Sertliğinin Point Shear Wave Elastografi ile Değerlendirilmesi

Özdemir

Can

Yilmaz

et al. 2022

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

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“…A study of healthy children and adolescents concluded that gender influences elastography at the spleen[ 43 ]. The influence of BMI on spleen shear wave velocity was not clear according to other research groups[ 21 , 33 , 44 ]. The influence of abdominal wall thickness on shear wave velocities has not yet been clarified[ 17 , 19 , 20 , 26 ] and this parameter was not assessed in our study.…”

Section: Discussionmentioning

confidence: 87%

“…This was not possible for the Philips device (p-SWE). Most of the available studies could not prove any gender-specific influence on the shear wave velocities[ 21 , 35 , 42 , 44 ]. A study of healthy children and adolescents concluded that gender influences elastography at the spleen[ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of point and two-dimensional shear wave elastography of the spleen in healthy subjects

Nowotny¹,

Schmidberger²,

Schlingeloff³

et al. 2021

WJR

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BACKGROUND Few systematic comparative studies of the different methods of physical elastography of the spleen are currently available. AIM To compare point shear wave and two-dimensional elastography of the spleen considering the anatomical location (upper, hilar, and lower pole). METHODS As part of a prospective clinical study, healthy volunteers were examined for splenic elasticity using four different ultrasound devices between May 2015 and April 2017. The devices used for point shear wave elastography were from Siemens (S 3000) and Philips (Epiq 7), and those used for two-dimensional shear wave elastography were from GE (Logiq E9) and Toshiba (Aplio 500). In addition, two different software versions (5.0 and 6.0) were evaluated for the Toshiba ultrasound device (Aplio 500). The study consisted of three arms: A, B, and C. RESULTS In study arm A, 200 subjects were evaluated (78 males and 122 females, mean age 27.9 ± 8.1 years). In study arm B, 113 subjects were evaluated (38 men and 75 women, mean age 26.0 ± 6.3 years). In study arm C, 44 subjects were enrolled. A significant correlation of the shear wave velocities at the upper third of the spleen ( r = 0.33088, P < 0.0001) was demonstrated only for the Philips Epiq 7 device compared to the Siemens Acuson S 3000. In comparisons of the other ultrasound devices (GE, Siemens, Toshiba), no comparable results could be obtained for any anatomical position of the spleen. The influencing factors age, gender, and body mass index did not show a clear correlation with the measured shear wave velocities. CONCLUSION The absolute values of the shear wave elastography measurements of the spleen and the two different elastography methods are not comparable between different manufacturers or models.

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“…When comparing the overall values of liver and spleen shear wave velocity in these two groups, values in the unfavorable prognosis group was significantly higher than in the favorable prognosis group. This demonstrates that there is a potential relationship between liver and spleen shear wave velocity and the prognosis of patients with portal hypertension[ 9 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical value of liver and spleen shear wave velocity in predicting the prognosis of patients with portal hypertension

Zhang¹,

Mao²,

Zhang³

et al. 2017

WJG

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AIMTo explore the relationship of liver and spleen shear wave velocity in patients with liver cirrhosis combined with portal hypertension, and assess the value of liver and spleen shear wave velocity in predicting the prognosis of patients with portal hypertension.METHODSAll 67 patients with liver cirrhosis diagnosed as portal hypertension by hepatic venous pressure gradient in our hospital from June 2014 to December 2014 were enrolled into this study. The baseline information of these patients was recorded. Furthermore, 67 patients were followed-up at 20 mo after treatment, and liver and spleen shear wave velocity were measured by acoustic radiation force impulse at the 1st week, 3rd month and 9th month after treatment. Patients with favorable prognosis were assigned into the favorable prognosis group, while patients with unfavorable prognosis were assigned into the unfavorable prognosis group. The variation and difference in liver and spleen shear wave velocity in these two groups were analyzed by repeated measurement analysis of variance. Meanwhile, in order to evaluate the effect of liver and spleen shear wave velocity on the prognosis of patients with portal hypertension, Cox’s proportional hazard regression model analysis was applied. The ability of those factors in predicting the prognosis of patients with portal hypertension was calculated through receiver operating characteristic (ROC) curves.RESULTSThe liver and spleen shear wave velocity in the favorable prognosis group revealed a clear decline, while those in the unfavorable prognosis group revealed an increasing tendency at different time points. Furthermore, liver and spleen shear wave velocity was higher in the unfavorable prognosis group, compared with the favorable prognosis group; the differences were statistically significant (P < 0.05). The prognosis of patients with portal hypertension was significantly affected by spleen hardness at the 3rd month after treatment [relative risk (RR) = 3.481]. At the 9th month after treatment, the prognosis was affected by liver hardness (RR = 5.241) and spleen hardness (RR = 7.829). The differences between these two groups were statistically significant (P < 0.05). The ROC analysis revealed that the area under the curve (AUC) of spleen hardness at the 3rd month after treatment was 0.644, while the AUCs of liver and spleen hardness at the 9th month were 0.579 and 0.776, respectively. These might predict the prognosis of patients with portal hypertension.CONCLUSIONSpleen hardness at the 3rd month and liver and spleen shear wave velocity at the 9th month may be used to assess the prognosis of patients with portal hypertension. This is hoped to be used as an indicator of predicting the prognosis of patients with portal hypertension.

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New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers

Cited by 8 publications

References 29 publications

Sağlıklı Bireylerde Dalak Sertliğinin Point Shear Wave Elastografi ile Değerlendirilmesi

Sağlıklı Bireylerde Dalak Sertliğinin Point Shear Wave Elastografi ile Değerlendirilmesi

Comparison of point and two-dimensional shear wave elastography of the spleen in healthy subjects

Clinical value of liver and spleen shear wave velocity in predicting the prognosis of patients with portal hypertension

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