New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

Salehi, Mehdi; Faghani, Fatemeh; Kubicki, Maciej; Bayat, Mehdi

doi:10.1007/s13738-018-1412-1

Cited by 34 publications

(13 citation statements)

References 66 publications

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“…The first band was assigned to π → π* transitions whilst the latter corresponded to the ligand-to-metal charge transfer (LMCT) transition. This is supported by the data from previous studies related to copper complexes [ 27 , 28 , 29 ]. Since Cu(II) complexes exhibit paramagnetism characteristics, the electron paramagnetic resonance (EPR) spectroscopy was utilized to provide relevant information on the geometry and electronic structure of the complexes.…”

Section: Resultssupporting

confidence: 88%

Efficient Catalytic Reduction of 4-Nitrophenol Using Copper(II) Complexes with N,O-Chelating Schiff Base Ligands

et al. 2021

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The reduction of 4-nitrophenol to 4-aminophenol by sodium borohydride was used as a model to test the catalytic activity of copper(II) complexes containing N,O-chelating Schiff base ligands. In this study, a series of copper(II) complexes containing respective Schiff base ligands, N′-salicylidene-2-aminophenol (1), N′-salicylidene-2-aminothiazole (2), and N,N′-bis(salicylidene)-o-phenylenediamine (3), were synthesized and characterized by elemental analysis, Fourier transform infrared (FT-IR), and UV-Visible (UV-Vis) and electron paramagnetic resonance (EPR) spectroscopies. The results from the 4-nitrophenol reduction showed that 3 has the highest catalytic activities with 97.5% conversion, followed by 2 and 1 with 95.2% and 90.8% conversions, respectively. The optimization of the catalyst amount revealed that 1.0 mol% of the catalyst was the most optimized amount with the highest conversion compared to the other doses, 0.5 mol% and 1.5 mol%. Recyclability and reproducibility tests confirmed that all three complexes were active, efficient, and possess excellent reproducibility with consistent catalytic performances and could be used again without a major decrease in the catalytic activity.

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Section: Resultssupporting

confidence: 88%

Efficient Catalytic Reduction of 4-Nitrophenol Using Copper(II) Complexes with N,O-Chelating Schiff Base Ligands

et al. 2021

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“…Their syntheses involve the condensation reaction of primary amines with active carbonyl in the presence of a suitable solvent . These metal complexes are prepared via the addition of the Schiff-base ligand to a metal precursor in an appropriate ratio together with suitable experimental conditions. , Myriad applications of Schiff bases and their metal complexes have been reported . Researchers have employed them as chelating ligands in coordination chemistry, ,, as a catalyst, − as a dye, , as an initiator in polymerization, and as luminescent compounds. , Biologically, they have been tested as antibacterial, − antifungal, − antitumor, − and antiviral , agents including insecticides. − …”

Section: Introductionmentioning

confidence: 99%

Design of New Schiff-Base Copper(II) Complexes: Synthesis, Crystal Structures, DFT Study, and Binding Potency toward Cytochrome P450 3A4

et al. 2021

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We report the synthesis and crystal structures of three new copper(II) Schiff-base complexes. The complexes have been characterized by elemental analysis and Fourier transform infrared (FT-IR) and UV–visible spectroscopies. The X-ray diffraction (XRD) analysis reveals that complexes 1 and 3 crystallize in a monoclinic space group C2/c and 2 in a triclinic space group P1̅, each adopting a square planar geometry around the metal center. We use a density functional theory method to explore the quantum chemical properties of these complexes. The calculation proceeds with the three-dimensional (3D) crystal structure characterization of the complexes in which the calculated IR and UV–vis values are comparable to the experimental results. Charge distribution and molecular orbital analyses enabled quantum chemical property prediction of these complexes. We study the drug-likeness properties and binding potentials of the synthesized complexes. The in silico outcome showed that they could serve as permeability-glycoprotein (P-gp) and different cytochrome P450 substrates. Our calculations showed that the complexes significantly bind to cytochrome P450 3A4.

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“…This in turn signifies that N and O are coordinated with the metal ion, and also, ϑ M  Cl vibrations, at 285 and 245 cm −1 , respectively, in complexes 1 and 2 show Cl − coordinated with metal ions under study. [ 45 ] Hence, IR spectra propose bi‐dentate behaviour of the ligand. The IR spectral data are shown in Table 3, and the spectrum in Figure S3.…”

Section: Resultsmentioning

confidence: 99%

Studies on DNA binding, cleavage, molecular docking, antimicrobial and anticancer activities of Cr(III), Fe(III), Co(II) and Cu(II) complexes ofo‐vanillin and fluorobenzamine Schiff base ligand

Bengi

Maddikayala

Reddy

2022

Applied Organom Chemis

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The ligand [2‐((2‐fluorophenylimino)methyl)‐6‐methoxyphenol] and its metal complexes [Cr(HL)2] (1), [Fe(HL)2] (2), [Co(HL)2] (3) and [Cu(HL)2] (4) are synthesized. Characterization of the complexes by sophisticated analytical techniques revealed the geometry around central metal ion to be octahedral for 1, 2 and 3 complexes and complex 4 with square planar geometry. Kinetic parameters of the complexes were estimated by the Coats–Redfern method, and the complexes were found to be thermally stable. DNA binding affinity of these metal complexes was explored by means of fluorescence, UV–visible and viscosity studies, and the studies suggested intercalative mode. Kb and KSV values were determined from the absorption and fluorescence studies for the synthesized complexes. Nuclease studies in the presence of H2O2 were performed using pUC19 supercoiled DNA. Docking studies were done using human DNA topoisomerase‐I (DNA topo I) receptor protein. Biological studies revealed higher activity for complexes than the ligand, and in vitro antitumour studies showed that complexes 3 and 4 possess potential inhibitory efficiency with an IC50 of 48.79 ± 0.7 and 39.74 ± 1.6 μg/ml, respectively. Molecular docking studies were carried out using Argus labs, and geometry optimization is performed. Molecular orbital calculations of the ligand and complexes are computed using the reasonably accurate parametric model PM3 method 16–19.

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New complexes of Ni(II) and Cu(II) with tridentate ONO Schiff base ligand: synthesis, crystal structures, electrochemical and theoretical investigation

Cited by 34 publications

References 66 publications

Efficient Catalytic Reduction of 4-Nitrophenol Using Copper(II) Complexes with N,O-Chelating Schiff Base Ligands

Efficient Catalytic Reduction of 4-Nitrophenol Using Copper(II) Complexes with N,O-Chelating Schiff Base Ligands

Design of New Schiff-Base Copper(II) Complexes: Synthesis, Crystal Structures, DFT Study, and Binding Potency toward Cytochrome P450 3A4

Studies on DNA binding, cleavage, molecular docking, antimicrobial and anticancer activities of Cr(III), Fe(III), Co(II) and Cu(II) complexes ofo‐vanillin and fluorobenzamine Schiff base ligand

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