New composite materials based on alginate and hydroxyapatite as potential carriers for ascorbic acid

Ilie, Andreia; Ghiţulică, Cristina; Andronescu, Ecaterina; Cucuruz, Andreia; Ficai, Anton

doi:10.1016/j.ijpharm.2016.01.025

Cited by 25 publications

(14 citation statements)

References 21 publications

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“…For example, nanorods/ nanoparticles have been applied for the controlled release of various proteins and drugs [13,227,259]. HAp is mainly used to provide antibiotics to hard tissues [177,241,260], and other drugs as anticancer substances [261][262][263], antiinflammatory drugs [264][265][266], anti-osteoporotic substances [267][268][269][270], and other molecules such as vitamins, hormones, proteins, and growth factors [260,271,272]. For drug release, HAp should have differentiated morphologies that allow the loading of the high capacity of drugs, such as HAp microspheres with a hollow structure, which facilitate the loading of drugs and their controlled release [172].…”

Section: Drug Delivery Systemmentioning

confidence: 99%

“…These materials can be found in gel form or not; the former being widely used because of its similarity to extracellular fluids [348]. The natural polymers used are chitosan [239,[349][350][351], gelatin [241,248,352], alginate [271,346,353], collagen [354,355], cellulose [352,356], and silk fibroin [357,358]. Among the most used synthetics we have poly(vinyl alcohol) (PVA) [241,352,359], poly(methyl methacrylate) (PMMA) [360], polycaprolactone (PCL) [360], polylactic-co-glycolic acid (PLGA) [361], poly(lactic acid)(PLA) [337,362], etc.…”

Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

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A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

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Section: Drug Delivery Systemmentioning

confidence: 99%

Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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“…The extended release period is possibly due to the existence of diffusion pathways, where the active ingredient is released by this effect or by pre-existing pores in the polymer [40,41]. Both the rupture and latency mechanisms were observed in studies with different polysaccharides [21,39,42,43]. Controlled release by microcapsule The results are averages ± standard deviation.…”

Section: Ascorbic Acid Release From Xyloglucan Microparticlesmentioning

confidence: 99%

Xyloglucan from Hymenaea courbaril var. courbaril seeds as encapsulating agent of l-ascorbic acid

Farias

Albuquerque

Soares

et al. 2018

International Journal of Biological Macromolecules

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This study evaluated the l-ascorbic acid (AA) encapsulation in microparticles of xyloglucan (XAA) extracted from Hymenaea courbaril seeds by spray drying (SD) and its application in tilapia fish burgers. The encapsulation efficiency was 96.34±1.6% and the retention of the antioxidant activity was of 89.48±0.88% after 60days at 25°C. SEM images showed microspheres with diameters ranging from 4.4 to 34.0μm. FTIR spectrum confirmed the presence of AA in xyloglucan microparticles, which was corroborated by DSC and TGA. The release of ascorbic acid was found to be pH-dependent. The application of XAA in tilapia fish burger did not change the pH after heating and the ascorbic acid retention was greater compared to its free form. The results indicate that xyloglucan can be used to encapsulate AA by SD and suggest that XAA was able to reduce undesirable organoleptic changes in fish burgers.

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“…These are similar to mineral component that present in bones and hard tissues [1]. The combination of ceramic based materials such as hydroxyapatite and natural polymer as sodium alginate will provide strength, stiffness and fracture toughness to the bone [2,3].The composite materials have been used in load bearing application such as filler and bone defect.…”

Section: Introductionmentioning

confidence: 99%

“…In this work, sodium alginates (SA) were used to improve the physical and mechanical properties of ceramic materials. Sodium alginate act as a hydrophilic and it can be dissolved in water but not entirely soluble [1].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Sintering Temperature on Densification and Mechanical Properties of Hydroxyapatite/Sodium Alginate Biocomposites

et al. 2017

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Abstract. Hydroxyapatite (HA) has been studied for their excellent performances which are suitable for use in bone defects or regeneration of bone. Hydroxyapatite (HA) has poor mechanical properties which make it limited used in a load bearing area. In this case, sodium alginate (SA) was used to be mixed with hydroxyapatite (HA) by using precipitation method to increase the mechanical and physical properties. The mixing of hydroxyapatite/sodium alginate effectively increases the densification and hardness of hydroxyapatite. It could contribute to the development of the artificial implants of hydroxyapatite (HA) for bone implants applications in load bearing area. The behaviors during densification were studied together with the mechanical properties of samples. The influence of mixed powder and the sintering temperature on densification, microstructure and mechanical properties of hydroxyapatite (HA)/sodium alginate (SA) composite were studied. The maximum density were attained by 99.5/0.5% (HA/SA) at 1.47g/cm3 and 1.82g/cm3 for both temperature 1000°C and 1100°C respectively while, the maximum values of hardness were also attained by 99.5/0.5% for temperature 1000°C and 1100°C at 0.053GPa and 0.266GPa respectively.

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New composite materials based on alginate and hydroxyapatite as potential carriers for ascorbic acid

Cited by 25 publications

References 21 publications

A brief review on hydroxyapatite production and use in biomedicine

A brief review on hydroxyapatite production and use in biomedicine

Xyloglucan from Hymenaea courbaril var. courbaril seeds as encapsulating agent of l-ascorbic acid

The Effects of Sintering Temperature on Densification and Mechanical Properties of Hydroxyapatite/Sodium Alginate Biocomposites

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