1998
DOI: 10.1002/(sici)1098-2752(1998)18:4<263::aid-micr9>3.0.co;2-k
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New concepts and materials in microvascular grafting: Prosthetic graft endothelial cell seeding and gene therapy

Abstract: Microsurgical free tissue transfer is currently associated with very high success rates and few complications. While interposition vein grafting is clearly an important adjunct to the microsurgeon's armamentarium, it has been associated with higher free flap/replantation failures and complication rates. With appropriate flap planning and surgical techniques, the need for interposition vein grafting should be quite infrequent and hopefully avoided if at all possible. Nevertheless, when necessary, the vein graft… Show more

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Cited by 5 publications
(2 citation statements)
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“…To date, this approach has not been successful. Because of poor adhesion in response to the shear stresses experienced by the cells under blood flow, the cells detach from the vascular graft surface 1, 2. Physiologic in vivo shear stresses range from 1 dyne/cm 2 in large veins to 20–40 dynes/cm 2 in arteries 3.…”
Section: Introductionmentioning
confidence: 99%
“…To date, this approach has not been successful. Because of poor adhesion in response to the shear stresses experienced by the cells under blood flow, the cells detach from the vascular graft surface 1, 2. Physiologic in vivo shear stresses range from 1 dyne/cm 2 in large veins to 20–40 dynes/cm 2 in arteries 3.…”
Section: Introductionmentioning
confidence: 99%
“…allografts and the implantation of artificial vascular prostheses could help in this indication. Whereas allografts may be potentially infectious and show signs of rejection, small-diameter vascular prostheses made of polytetrafluoroethylene (PTFE) show low patency rates [1]. The luminal surface of PTFE lacks an endothelial layer that prevents thrombosis and the formation of a hyperplastic neointima.…”
mentioning
confidence: 99%