New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat

Elliott, Jonathan; Geddes, Rebecca

doi:10.1016/j.tvjl.2022.105842

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…This is further proof that both the total amount of ingested phosphate and its source are responsible for the effects on calcium and phosphorus metabolism. Previously, a SUL for inorganic phosphate intake of 1 g/Mcal in cats has been suggested [95,96]. This recommendation was based on results from medium-term studies in cats using primarily sodium tripolyphosphate (STPP).…”

Section: Discussionmentioning

confidence: 99%

The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

2023

J Urol Ren Dis

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Chronic Kidney Disease (CKD) is an increasingly frequent disease in geriatric cats, representing the leading cause of death in this species. Reports about the increasing prevalence of CKD exist also in human medicine. The intake of nutrients, notably phosphorus, can affect renal health. Dietary supply with phosphate can influence concentrations of phosphate and factors of the phosphate homeostasis in blood and urine, possibly causing adverse health effects. Investigating nutritional factors involved in the cause and aggravation of kidney damage in more detail is of high importance not only for feline health. The cat is already successfully used as model for various human diseases which highlights its potential role as translational model for phosphate toxicity in humans. Effects of the food additives H 3 PO 4 and NaH 2 PO 4 on phosphorus homeostasis were investigated in comparison to a control diet. Adding these highly available phosphate additives to the diet of healthy cats for 28 days caused a significant increase in serum phosphate, calcium, and FGF23 as well as in renal phosphorus excretion. Consequently, the use of both phosphate additives in food processing needs to be critically re-evaluated due to the high availability of these sources and therefore their potential adverse health effects. With up to 80 % prevalence, Chronic Kidney Disease (CKD) is one of the most common chronic diseases in geriatric cats [1,2], and represents the leading cause of death in this species [3]. Reports of the increasing prevalence of CKD in the last decades also exist in human medicine [4]. It has been shown in various species, including humans and cats, that the supply of nutrients, notably phosphorus, can affect renal health [5][6][7]. To investigate nutritional factors involved in cause and aggravation of kidney damage in more detail is therefore of high importance not only for feline health. The fact that the cat has been successfully used as a model for human diseases in several studies [8][9][10][11][12] supports its potential role as translational model for human medicine.

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Section: Discussionmentioning

confidence: 99%

The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

2023

J Urol Ren Dis

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Sodium glucose transporter 2 inhibitors: Will these drugs benefit non‐diabetic veterinary patients with cardiac and kidney diseases?

Elliott,

Oyama

2024

Vet Pharm & Therapeutics

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Sodium glucose transporter type 2 (SGLT2) inhibitors have been introduced into human medicine where their beneficial effects go beyond the expected improvement in blood glucose control. These drugs appear to prevent progression of both cardiovascular and kidney diseases, not only in diabetic but also in non‐diabetic human patients. As these drugs have received conditional approval for use in diabetic cats and are being used in other veterinary species, the intriguing question as to whether they will have similar cardioprotective and nephroprotective effects in dogs and cats is being asked. The primary mechanism(s) by which SGLT2 inhibitors are cardio‐ and nephroprotective remain to be fully characterized. This paper reviews these suggested mechanisms in the context of the pathophysiology of progressive cardiovascular and kidney diseases in dogs and cats with the goal of predicting which categories of non‐diabetic veterinary patients these drugs might be of most benefit.

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New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat

Cited by 2 publications

References 55 publications

The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

Sodium glucose transporter 2 inhibitors: Will these drugs benefit non‐diabetic veterinary patients with cardiac and kidney diseases?

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