New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins

Lanza, Valeria; Vecchio, Graziella

doi:10.1016/j.jinorgbio.2008.11.017

Cited by 43 publications

(24 citation statements)

References 58 publications

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“…For the evaluation of MnSOD activity, KCN 2 mM was added to the reaction. Catalase activity was assayed by polarographic, monitoring the conversion of hydrogen peroxide to oxygen, using a Clark-type oxygen electrode (after Lanza and Vecchio, 2009). The reaction medium contained potassium phosphate buffer (KH 2 PO 4 50 mM, EDTA 1 mM, pH ¼7.5) and H 2 O 2 (12.5 mM), and the reaction was started by adding the sample (diluted 250-fold).…”

Section: Sampling and Processing Of Biological And Ecological Indicatorsmentioning

confidence: 99%

A multiple index integrating different levels of organization

Cortes

Hughes

Coimbra

et al. 2016

Ecotoxicology and Environmental Safety

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Section: Sampling and Processing Of Biological And Ecological Indicatorsmentioning

confidence: 99%

A multiple index integrating different levels of organization

Cortes

Hughes

Coimbra

et al. 2016

Ecotoxicology and Environmental Safety

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“…The mechanism by which each Mn-salen complex acts as a superoxide dismutase mimetic involves the reduction of Mn(III) to Mn(II) by O 2 -· resulting in production of O 2 . The Mn(II) is oxidized back to Mn(III) by another molecule of O 2 -· yielding H 2 O 2 [12]. The protective effects of these antioxidants against oxidative stress-induced injuries have been reported in many in vitro and in vivo disease models, including, stroke, amyotrophic lateral sclerosis, Parkinson [13], excitotoxic neuronal injury [14] and adult respiratory distress syndrome [15].…”

Section: Introductionmentioning

confidence: 99%

Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress

2012

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Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis (accumulation of triacylglycerols within hepatocytes) along with inflammation and ballooning degeneration. It has been suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. The aim of present study was to determine whether antioxidant supplementations using EUK-8, EUK-134 and vitamin C could improve the biochemical and histological abnormalities associated with diet-induced NASH in rats. Methods: NASH was induced in male N-Mary rats by feeding a methionine -choline deficient (MCD) diet. The rats were fed either normal chow or MCD diet for 10 weeks. After NASH development, the MCD-fed rats were randomly divided into four groups of six: the NASH group that received MCD diet, the EUK-8 group which was fed MCD diet plus EUK-8, the EUK-134 group which was fed MCD diet plus EUK-134 and the vitamin C group which received MCD diet plus vitamin C. EUK-8, EUK-134 and vitamin C (30 mg/kg body weight/day) were administered by gavage for eight weeks. Results: Treatment of MCD-fed rats with salens reduced the sera aminotransferases, cholesterol, low density lipoprotein contents, the extent of lipid peroxidation and protein carbonylation whereas the HDL-C cholesterol levels were significantly increased. In addition, EUK-8 and EUK-134 improved steatosis, ballooning degeneration and inflammation in liver of MCD-fed rats. Conclusion: Antioxidant (EUK-8, EUK-134 and vitamin C) supplementation reduces NASH-induced biochemical and histological abnormalities, pointing out that antioxidant strategy could be beneficial in treatment of NASH.

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“…[3][4][5][6] In such ac ontext, we have previously synthesized and evaluated CD conjugates that have demonstrated interestingf eatures such as the enhancement of solubility,d ecrease of cytotoxicity,i nclusion capacity,a ntioxidant, chelating and antiaggregant ability. [7][8][9][10][11][12] In particular, CDs functionalized with chelating aromatic moieties have shown ap owerful inhibitory effect on amyloid-beta (Ab)a nd alpha-synuclein aggregation. [13,14] These proteinsa re involved in neurodegenerative disorderss uch as Alzheimer's disease (AD) and Parkinson's disease (PD).…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Nanoparticles Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Biomaterials

Oliveri

Bellia

Vecchio

2017

Chemistry A European J

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Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal-chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal-chelating β-cyclodextrin polymer bearing 8-hydroxyquinoline ligands. The metal ions (Cu or Zn ) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self- and metal-induced Aβ aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble β-cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials.

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New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins

Cited by 43 publications

References 58 publications

A multiple index integrating different levels of organization

A multiple index integrating different levels of organization

Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress

Cyclodextrin Nanoparticles Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Biomaterials

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