New Constituents From the Roots and Stems of <i>Paramignya trimera</i>

Hương, Trần Thu; Hà, Vũ Thị Thu; Cuong, To Dao; Toàn, Trần Quốc; Anh, Hoang Thi Ngoc; Tram, Nguyen Thị Thu; Woo, Seung Hyo; Kim, Young Ho; Cường, Nguyễn Mạnh

doi:10.1177/1934578x19861015

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Exopolysaccharides extracted from Ophiocordyceps sinensis (0.83 g/kgP or 1.66 g/kgP) showed a significant hepatoprotective effect against CCl 4 -induced hepatotoxicity in rats by increasing GSH, decreasing MDA levels, and decreasing serum AST and ALT activities. The improvement in liver tissue demonstrated that EPS significantly lessened the damage that CCl4 caused to the liver [70].…”

Section: H Glc Rhamentioning

confidence: 97%

“…A phytochemical study of P. trimera roots (Xáo tam phân) revealed the presence of a variety of coumarins and coumarin glycosides, including simple coumarins (ostruthin, ninhvanins A-B, 6-(6-hydroxy-3,7-dimethylocta-2,7-dienyl)-7-hydroxycoumarin, esculetin, and scopoletin) [70,71] and biscoumarin monoterpene glycosides such as paratrimerins A-B and paratrimerins J-Y [72,73]. Both the methanol extract and the water decoction of P. trimera roots showed hepatoprotective activities in PAR-induced liver damage mice.…”

Section: -Si)mentioning

confidence: 99%

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Studies on hepatoprotective effects of Vietnamese medicinal plants

Pham,

Bauerova,

Manh Cuong

2023

Vietnam J. Sci. Technol.

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The liver is a major organ of the human and animal body, playing an important role in metabolism, detoxification and immunomodulation. When liver tissue is damaged, liver function will decrease, leading to liver diseases such as liver fibrosis, cirrhosis, and liver cancer. Medicinal plants and natural products have provided a source of new drug candidates for the prevention and treatment of liver diseases. This review is based on scientific publications on Vietnamese plants investigated for their hepatoprotective activity during the period from 1998 to 2022. 51 medicinal plants, 38 phytoconstituents, and 8 hepatoprotective herbal formulations of Vietnamese-origin have been reported to protect the liver from the harmful effects induced by hepatotoxins, typically CCl4 or paracetamol. Each plant's information, including its botanical name, family, part of the plant used, local name, chemical constituents, extracts or fractions used, dosage, model used, parameters obtained, histopathology, and results of hepatoprotective studies, is displayed. Also discussed is the possible mechanism of action of these hepatoprotective plants.

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Section: H Glc Rhamentioning

confidence: 97%

Section: -Si)mentioning

confidence: 99%

Studies on hepatoprotective effects of Vietnamese medicinal plants

Pham,

Bauerova,

Manh Cuong

2023

Vietnam J. Sci. Technol.

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“…Phytochemical and pharmacological studies of medicinal plants have made substantial progress in recent years, with an emphasis on novel molecules with therapeutic qualities. 11–17 The focus of this section is on publications over the last 40 years that deal with phytochemical investigations of Tupistra species. Up to now, approximately 200 compounds with diverse chemical structures have been isolated from the Tupistra genus, but steroid derivatives have predominated.…”

Section: Phytochemistrymentioning

confidence: 99%

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Linh

Son

2022

Natural Product Communications

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In the current paper, secondary metabolites separated from Tupistra plants have been reviewed. Approximately 200 phytochemicals, classified in various chemical classes of bioactive compounds, have been compiled, along with their sources and references. The most striking feature is that the most frequently isolated compounds have been spirostanol sapogenins, and spirostanol and furostanol saponins, most of which are new in nature. The application of both Tupistra plant extracts and isolated compounds in biological assays is also one of the crucial aims in pharmacological discoveries. Tupistra constituents have demonstrated valuable properties in the field of pharmacology, such as antioxidative, antimicrobial, antidiabetic, and antihepatic activities, but their cytotoxic and anti-inflammatory actions can be considered as the more remarkable. In vivo cancer-related activities of the tested Tupistra samples were mostly based on apoptosis. Further phytochemical investigations, together with extensive assessments of the biological profiles and mechanism of action studies of the components of Tupistra species are to be expected.

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Phylogenetic relationship of Paramignya trimera and its relatives: an evidence for the wide sexual compatibility

Phi

Chu

et al. 2020

Sci Rep

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The genus Paramignya (Rutaceae) comprises about 30 species typically distributing in tropical Asia. Like other genera of the family Rutaceae, the significant variation in the morphology of Paramignya species makes the taxonomic study and accurate identification become difficult. In Vietnam, Paramignya species have been mostly found in Khanh Hoa and Lam Dong provinces and used as traditional medicines. Recently, Paramignya trimera, a species of the genus Paramignya with local name “Xao tam phan” has been drawn attention and intensively exploited to treat liver diseases and cancers. However, the significant variations in the morphology and different local names of P. trimera have caused confusion and difficulty in the accurate identification and application of this plant for medicine. In this study, the combination of both morphological and DNA sequence data has effectively supported the taxonomic identification of P. trimera and some relatives collected in Khanh Hoa and Lam Dong provinces. The comparison of the morphology and analysis of the phylogenetic trees suggested that there was a significant variation of P. trimera. In addition, some accessions of P. trimera with morphological characteristics similar and Atalantia buxifolia were likely the intergeneric hybrids between the two species. Analysis of genetic variation, interspecific and intraspecific distances using ITS, matK and rbcL sequences shown that P. trimera was closely related to A. buxifolia, Severinia monophylla and Luvunga scandens. In addition, matK sequences represented as the effective candidate DNA barcode to identify and distinguish Paramignya species from others of the family Rutaceae.

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New Constituents From the Roots and Stems of Paramignya trimera

Cited by 5 publications

References 19 publications

Studies on hepatoprotective effects of Vietnamese medicinal plants

Studies on hepatoprotective effects of Vietnamese medicinal plants

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Phylogenetic relationship of Paramignya trimera and its relatives: an evidence for the wide sexual compatibility

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