New Constituents from the Roots of Erythrina x bidwillii

Abstract

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A new Erythrina alkaloid from Erythrina herbacea

“…Erythrina alkaloids are well known to have a curare-like action [1], and among them, a few Erythrina compounds (erysodine and 11a-hydroxyerysodine) demonstrated radical scavenging properties against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical [2]. During the course of our continuing studies on plants in the genus Erythrina [3], we investigated the constituents of Erythrina herbacea L. The plant is found throughout the southeastern United States and northeastern Mexico, and grows as a low shrub or small tree with showy scarlet flowers. The flowers and seeds of E. herbacea are used by the Tenek ethnic group, Mexico, as a tranquilizing agent [4].…”

Prenylated Isoflavonoids: Botanical Distribution, Structures, Biological Activities and Biotechnological Studies. An Update (1995 – 2006)

“…; eryvarins H, i.e. 2-(4'-hydroxy-2',5'dimethoxy phenyl)-6-hydroxybenzofuran-3-carbaldehyde; eryvarin Q (88q, prenylated arylbenzofuran), and eryvarin R, the unusual 3-(4'-hydroxy-2',5'-dimethoxyphenyl)-2,3-dihydro-6-hydroxybenzofuran-3-carbaldehyde [59]; eryvarin S (11s), T (7,4'-dihydroxy-2',5'-dimethoxyisoflavone), and the rare eryvarin U (88u) [60]. 2-(4'-hydroxy-2',5'dimethoxy phenyl)-6-hydroxybenzofuran-3-carbaldehyde; eryvarin Q (88q, prenylated arylbenzofuran), and eryvarin R, the unusual 3-(4'-hydroxy-2',5'-dimethoxyphenyl)-2,3-dihydro-6-hydroxybenzofuran-3-carbaldehyde [59]; eryvarin S (11s), T (7,4'-dihydroxy-2',5'-dimethoxyisoflavone), and the rare eryvarin U (88u) [60].…”

“…The drawings of structures 15a and 15b were corrected in [72b]; 12 rotenoids (57a-k), including an unusual chloro derivative (57c), the four isomers of 4'-5'-dihydro-4'-5'-dihydroxytephrosin (57hk), a 6-keto-dehydroderivative (58) and an oxo-rotenoid (59) [73a]. (Lonchocarpus utilis and L. urucu) [South America]: cis-4", 5"-dihydro-4",5"dihydroxylonchocarpusone (15a), the dihydrodiol of the known lonchocarpusone (15b) [72a].…”

“…In spite of a large variety of structures, including simple (H) and complex (I, 73) isoflavenes or pterocarpans (J,K; 42j, 42k) [58], simple (M) and prenylated (N, 30n) isoflavanones or a 3-aryl coumarin (O, 80) [59], a preny-lated isoflavone (S, 11s) or 7,4'-dihydroxy-2',5'-dimethoxyisoflavan (T) [60], only 2arylbenzo-furans resulted active. In spite of a large variety of structures, including simple (H) and complex (I, 73) isoflavenes or pterocarpans (J,K; 42j, 42k) [58], simple (M) and prenylated (N, 30n) isoflavanones or a 3-aryl coumarin (O, 80) [59], a preny-lated isoflavone (S, 11s) or 7,4'-dihydroxy-2',5'-dimethoxyisoflavan (T) [60], only 2arylbenzo-furans resulted active.…”

“…In spite of a large variety of structures, including simple (H) and complex (I, 73) isoflavenes or pterocarpans (J,K; 42j, 42k) [58], simple (M) and prenylated (N, 30n) isoflavanones or a 3-aryl coumarin (O, 80) [59], a preny-lated isoflavone (S, 11s) or 7,4'-dihydroxy-2',5'-dimethoxyisoflavan (T) [60], only 2arylbenzo-furans resulted active. MBC values of 89q ranged from 6.25 to 25 μg/mL, comparable with those (313 to 25 μg/mL) of the highly active antibiotic mupirocin against the same MRSA strains [59]. Eryvarin Q (89q) inhibited the growth of 13 MRSA strains with a MIC 50 3.13 μg/mL, lower than those of erychristagallin (110a) and orientanol B (110b) [121].…”