New Coumarin Derivatives Accessible in Short and Eco-Friendly Conditions with Antifungal Activity

Abstract

Aim: The synthesis of a novel class of compounds bearing a coumarin entity was targeted. They are either iminocoumarins or characterized by the presence of a pyridone ring fused within the iminocoumarin scaffold. Methods & results: The targeted compounds were synthesized through a short method, thanks to microwave activation. The study evaluated the antifungal activity of 13 newly synthesized compounds against a new fungal strain of Aspergillus niger. The most active compound showed activity comparable to the widely used reference drug, amphotericin B. Conclusion: The conditions and the ease of synthesis warrant high potential of the method for diversity-oriented synthesis, very useful within the drug discovery area.

Annulated Heterocyclic[g]Coumarin Composites: Synthetic Approaches and Bioactive Profiling

“…The development of effective and accessible pharmaceutical molecules to address a wide range of illnesses is a primary focus of medicinal chemistry. Because they are versatile chemical entities with antiproliferative, [1] antiradical, [2] antibacterial, [3] antifungal, [4] antiviral, [5,6] inflammatory suppressant, [7] hepatoprotective, [8] cardioprotective, [9] neuroprotective, [10] antidiabetic, [11] and lipid-lowering [12] properties, coumarin-based compounds have drawn a lot of attention in recent decades. Figure 1 illustrates the structure of coumarin, a dicyclic molecule that is made up of a five-membered lactone ring fused with an arene ring.…”