New Cu (II) and Co(II) octaazamacrocyclic complexes with 2-amino-3-phenyl-propanoic acid

Abstract

New cationic Cu(II) and Co (II) complexes with N,N',N",4,8, and the anion of 2-amino-3-phenylpropanoic acid (S-phenylalanine) were prepared. The complexes were analyzed and characterized by elemental analysis, conductometric, polarimetric, magnetic and cyclic voltammetric measurements, as well as by spectroscopic data (UV/Vis, IR). Both complexes are binuclear with the general formula [M 2 (S-Phe)tpmc](ClO 4 ) 3 ·nH 2 O; S-PheH = S-phenylalanine, M(II) = Cu, n = 7; Co, n = 0. Based on previously reported data for some familiar complexes and the present results, pentacoordinated geometry was proposed. Both of the central metal ions are coordinated with two pyridyl and two cyclam nitrogens and bridged with -N-(CH 2 ) 3 -N-portions of the cyclam ring and oxygen atoms of the S-phenylalaninate ion. Antimicrobial screening of the complexes, solvent, starting salts and ligands alone was performed against fungi, mould and some bacteria. In certain cases, enhanced activity of Co(II) complex towards bacteria compared with the relevant free ligands and starting salts was detected.

Synthesis and characterization of copper (II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of Cu(II) and Co(II) analogous

“…22 In similar 5-coordinated Cu(II) complexes with carboxylate co-ligands the values of the magnetic moments are in the range of 1.75-2.20 μ B /Cu(II). 14,[23][24][25] However, similar values are reported for binuclear Cu(II) complexes with no magnetic interaction between the copper(II) ions as well. [23][24][25] 642 D R A Ž I Ć et al…”

“…The large width of the spectral bands, the position of λ max , and the shapes correspond to d-d transitions of the Cu(II) complexes. 26 The similarity of these spectra to the spectra of the related aminocarboxylate complex with S-phenylalanine and with numerous carboxylate Cu(II) complexes 14,[23][24][25] additionally supports the proposed five-coordinate geometry of Cu(II). There is a bathochromic shift of the absorption maximum in the case of complex 2 in comparison to complex 1.…”

Synthesis, characterization and biological study of new dinuclear zinc(II) and nickel(II) octaaza macrocyclic complexes

“…A sharp band at 1589.4 cm -1 , ascribed to pyridine ring skeletal vibration in the spectrum of free tpmc (Fig. 3a) is displaced to 1610 cm -1 upon coordination [4]. Strong broad bands at 1361.4-1295.3 cm -1 and 1021.3 cm -1 are assigned to coordinated nitrate [35].…”

“…In recent years, interest in macrocyclic polyamines has been on the increase as a result of their attractive structures and their possible applications in many different fields [1][2][3]. The reason for that is their possibility to react or coordinate with many different metal ions as well as organic molecules via by nitrogen atoms [4][5][6][7].…”

“…Until now, only a few metal complexes with coordinated tpmc have been synthesized [15][16][17][18][19][20][21], mostly with copper(II) ions, in dinuclear complexes [22][23][24]. These complexes have shown different electrochemical properties [25,26], as well as antibacterial [4,17] and cytotoxic activity [19,27,28]. According to our knowledge, this is the first report of the synthesis, characterization, and electrochemical and biological study of a dinuclear zinc complex with tpmc containing nitrato ion as a bridging ligand, as well as a dinuclear nickelnitrato complex with tpmc ligand.…”