New Cu(i) square grid-type and Ni(ii) triangle-type complexes: synthesis and characterization of effective binders of DNA and serum albumins

Abstract

Metallosupramolecular square grid-type complex [Cu4L4]4+ and triangle-type complex [Ni3L3]6+ as a potential strategy for obtaining versatile metal-based DNA, Serum Albumin (SA) and DNA binders.

The effect of ionic versus covalent functionalization of polyoxometalate hybrid materials with coordinating subunits on their stability and interaction with DNA

“…Herein, we aimed to elucidate the affinity of the hybrid compounds (ionic Hx ion vs. covalent Hx cov ) toward CT-DNA (deoxyribonucleic acid sodium salt from calf thymus), a model reagent used for routine DNA studies. 70 Since the electrostatic character of Hx ion –H1 (neutral), H2 (anionic) and H3 (anionic) is structure dependent, the interplay between them and DNA scaffold may be dissimilar to those previously described. At the same time, covalent functionalization of the POM hybrid can also be anticipated to help, especially since we did demonstrate previously that the silver( i ) helical complexes of the related tpy ligand bind nucleic acids.…”