New cytological findings on fine‐needle aspiration of renal collecting duct carcinoma

Sironi, Maria; Delpiano, Chiara; Claren, Rossella; Spinelli, Maurizio

doi:10.1002/dc.10357

Cited by 17 publications

(7 citation statements)

References 9 publications

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“…As transbronchial FNAB usually do not yield large tissue fragments, especially of vascular neoplasms, it is not always possible to see all the cytological features that have been described as characteristic of this carcinoma. The ramifying vascular network, basal membrane-like material and fibrous tissue component as described by Sironi et al, 6 Sarode et al 5 and Bejar et al 3 were not seen.…”

Section: Dear Dr Bedrossianmentioning

confidence: 74%

“…Their cytological morphology is less characteristic, with mainly small case reports in the literature describing fine-needle aspiration (FNA) and imprint cytology of the kidney tumour, metastasis and of desquamative urine cytology. [3][4][5][6] The features that are described include: tubules, sheets and papillary fragments of tumour. The nuclei are high grade with hyperchromatic chromatin and nucleoli.…”

Section: Dear Dr Bedrossianmentioning

confidence: 99%

“…3,5,6 Other features include fibrous tissue fragments, ramifying vascular network, hobnail appearance, basal membrane-like substance in epithelial clusters and neutrophilic infiltrate. 3,5,6 In aspirates of the renal primary, there can be an admixture of both normal tubules, tubules with dysplastic epithelium and frank malignant tubules. 5 We present a 26-year-old man who had a left nephrectomy for a collecting duct carcinoma (Fig.…”

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A uncommon cause of haemoptysis: Metastatic collecting duct renal carcinoma

Schubert

Louw

Scubert³

et al. 2010

Diagnostic Cytopathology

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Collecting duct renal carcinoma is a rare variant of renal cell carcinoma (RCC), accounting for about 1% of renal epithelial malignancies. 1,2 This is an aggressive variant of RCC with early lymph node and distant metastasis being common. 1,3 They occur in a wide age range, including young adults, with a mean age of 55 years. 1,4,5 Their histological appearance has been well described 1,2 with tumours showing predominantly a tubular or tubulopapillary growth pattern with mainly high-grade nuclei in a desmoplastic stroma. Their cytological morphology is less characteristic, with mainly small case reports in the literature describing fine-needle aspiration (FNA) and imprint cytology of the kidney tumour, metastasis and of desquamative urine cytology. 3-6 The features that are described include: tubules, sheets and papillary fragments of tumour. The nuclei are high grade with hyperchromatic chromatin and nucleoli. Cytoplasm varies in amount, is delicate, eosinophilic and occasionally can be vacuolated. 3,5,6 Other features include fibrous tissue fragments, ramifying vascular network, hobnail appearance, basal membrane-like substance in epithelial clusters and neutrophilic infiltrate. 3,5,6 In aspirates of the renal primary, there can be an admixture of both normal tubules, tubules with dysplastic epithelium and frank malignant tubules. 5 We present a 26-year-old man who had a left nephrectomy for a collecting duct carcinoma (Fig. 1). He subsequently received chemotherapy. Following surgery, the patient had to be started on haemodialysis for chronic renal failure due to malignant hypertension. He presented 6 months later with bright red spot haemoptysis for the past 3 weeks. He had no systemic complaints and no weight loss. Erythrocyte sedimentation rate (ESR) was 9 (normal), two sputum cultures showed no growth and two Zeihl Neelson stains were negative for mycobacteria. CT scan showed a right main bronchus tumour but no parenchymal infiltration (Fig. 2). At bronchoscopy, there was external compression of both the right middle and lower lob bronchi (Fig. 3). Transbronchial fine-needle aspiration biopsy (FNAB) was performed using a 22G Wang needle. One needle pass was very cellular yielding an epithelial malignancy. The patient subsequently started haemorrhaging and no further FNAB or biopsies could be performed.The cytology showed an adenocarcinoma, with morphology not typical of a high-grade adenocarcinoma of the lung. The features were more in keeping with a lowgrade (well-differentiated) adenocarcinoma. The carcinoma showed small cellular groups, micropapillary-like (Fig. 4) and numerous tubular structures (Fig. 5). Looselying cells were readily apparent. The nuclei ranged from medium to large in size, with irregular nuclear membranes, finely granular chromatin and small nucleoli. The cytoplasm was scant in amount with occasional vacuolated cells (Fig. 6).These features by themselves do not correspond to a specific diagnosis of a collecting duct carcinoma. As transbronchial FNAB usually do not yield large tissue ...

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Section: Dear Dr Bedrossianmentioning

confidence: 74%

Section: Dear Dr Bedrossianmentioning

confidence: 99%

mentioning

confidence: 99%

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A uncommon cause of haemoptysis: Metastatic collecting duct renal carcinoma

Schubert

Louw

Scubert³

et al. 2010

Diagnostic Cytopathology

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“…30,31 The cytologic features are the presence of a ramified vascular network, hobnail appearance of the cells, and basal membrane-like substance in most of the epithelial clusters.…”

Section: Microscopic Characteristicsmentioning

confidence: 99%

Collecting Duct Carcinoma of Kidney

Jordà¹,

Manoharan²

2006

Pathology Case Reviews

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Collecting duct carcinoma is a rare renal neoplasm that originates from the distal segment of the collecting duct in the renal medulla pyramids. Of all renal epithelial neoplasms, collecting duct carcinoma is the most aggressive, showing early metastatic behavior, poor prognosis, and limited response to immunotherapy. Recently, chemotherapy regimens commonly used for urothelial carcinoma have been demonstrated to be superior to the ones used for renal cell carcinoma in patients affected by this malignancy. Therefore, distinction between collecting duct carcinoma and other renal neoplasms involving renal medulla is desirable.

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“…Collecting duct RCC shows tubulopapillary architecture, atypical hyperplastic changes, clear cytoplasm, evident stromal reaction with fiber hyperplasia and detached single cells with a hobnail surface (10). CDC is a rare pathologic type of RCC, with a tendency towards early dissemination and high mortality rates (11)(12) The majority of CDC tumors have been found to demonstrate focal cortical extension, while perirenal invasion was also common in large tumors (13). This was a case of papillary and collecting duct and clear cell RCC in the same kidney and in a single tumor mass which also involved the perinephric fat.…”

Section: Case Reportmentioning

confidence: 99%

Renal Cell Carcinoma With Three Types of Morphologies- A Rare Entity

Siddqui¹,

Gupta²,

Zaidi³

et al. 2018

EJMR

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Renal cell carcinomas(RCC) are the most common solid lesions of kidney with commonest subtype being clear cell type. Very few studies have reported synchronous presentation of three different morphological variants of RCC. We present a case of renal cell carcinoma in a 50 year old female presenting with renal mass. Microscopic examination showed presence of papillary, clear cell and collecting duct types of morphologies, which is a rare finding. Hence thorough sectioning and microscopic examination should be done to rule out possibility of simultaneous presence of different morphological varieties of RCC.

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New cytological findings on fine‐needle aspiration of renal collecting duct carcinoma

Cited by 17 publications

References 9 publications

A uncommon cause of haemoptysis: Metastatic collecting duct renal carcinoma

A uncommon cause of haemoptysis: Metastatic collecting duct renal carcinoma

Collecting Duct Carcinoma of Kidney

Renal Cell Carcinoma With Three Types of Morphologies- A Rare Entity

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