New cytotoxic steroidal saponins from Cestrum parqui

Mosad, Radwa R.; Ali, Mohamed H.; Ibrahim, Magda T.; Shaaban, Mohammed; Emara, Marwan; Wahba, Amir E.

doi:10.1016/j.phytol.2017.09.022

Cited by 19 publications

(8 citation statements)

References 18 publications

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“…Cytotoxic activity is one of the most common reported for saponins, there are reported of this activity in families Agavaceae, Taccaceae, Orchidaceae, Dracaenaceae, Liliaceae, Amaryllidaceae, Asparagaceae, Solanaceae and others [31][32][33][34][35][36][37][38][39][40][41][42] . Three steroidal saponin from Allium flavum (Amaryllidaceae) exhibited moderate cytotoxicity against human colorectal cancer cell line (SW480) [31] .…”

Section: Cytotoxic Activitymentioning

confidence: 99%

“…Anemarrhena asphodeloides [40] Solanaceae Cestrum parqui [41] Asparagaceae Sansevieria cylindrica Bojer [42] Gastroprotective Liliaceae Paris polyphylla var.yunnanensis [43] Agavaceae Agave angustifoliva.var marginata [44] Alliaceae Allium ampeloprasum var. porrum [27] Anti-anoxia Selaginellaceae Selaginella uncinata [45] Anti-hyperlipidemia Dioscoreaceae Dioscorea nipponica [46] Anti-thrombotic Dioscoreaceae Dioscorea zingiberensis C.H.…”

Section: Asparagaceaementioning

confidence: 99%

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Therapeutic properties and structural characterization of steroidal saponins: a review

Pereira

Cruz

2021

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Saponinas esteroidais são uma importante classe de metabólidos secundários, estas são amplamente distribuídas em muitas espécies de plantas e são caracterizadas como princípio ativos destes produtos naturais. Saponinas tem sido investigadas ao longo dos anos, devido as suas potentes propriedades terapêuticas. Neste trabalho foram resumidos os estudos encontrados na literatura científica acerca das investigações das atividades biológicas e caracterização estrutural de saponinas esteroidais. Estudos recentes tem sugerido algumas saponinas como candidatas ao tratamento de pacientes com a doença do Coronavirus (COVID-19).

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Section: Cytotoxic Activitymentioning

confidence: 99%

Section: Asparagaceaementioning

confidence: 99%

Therapeutic properties and structural characterization of steroidal saponins: a review

Pereira

Cruz

2021

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“…In addition, several studies have also reported that this plant possess antiplatelet, anticancer, and spermicidal effects (Chenni et al 2015;Falkenberg et al 2012;Souad et al 2007). Moreover, previous phytochemical studies have shown that alkaloids and saponin extracts from leaves of C. parqui could be the main active compounds responsible of biological activities (Abdel-Gwad et al 1997;Baquai et al 2001;Brevis et al 1999;Chaieb et al 2007a;Mosad et al 2017;Silva et al 1962). Nevertheless, lignans, neolignans, andsesquilignans (D'Abrosca et al 2006;Fiorentino et al 2007); sapogenin (Bianchi et al 1963;Torres et al 1988), terpenoids (D'Abrosca et al 2004a(D'Abrosca et al , 2005Pearce et al 1992), and phenols (D'Abrosca et al 2004b) are also present in C. parqui leave extracts.…”

Section: Introductionmentioning

confidence: 98%

Antifeedant Activities of Organic Fractions from Cestrum parqui Leaves on the Red-Haired Bark Beetle Hylurgus ligniperda

Huanquilef

Espinoza

Mutis

et al. 2020

J Soil Sci Plant Nutr

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Hylurgus ligniperda is one of the most important quarantine forest insects associated to pine (Pinus radiate D. Don) logs exported from Chile. Methyl bromide fumigation has been the prominent control method. As the use of this synthetic insecticide leads to serious environmental problems, research to find alternative treatments is urgently needed for the Chilean forestry sector. Hence, plant secondary metabolites have been considered as an alternative for its control. Therefore, the objective of this work was to assess the feeding behavior of H. ligniperda through the artificial diet supplemented with organic fractions obtained from Cestrum parqui leaves. Organic extracts were obtained using a Soxhlet extraction. Non-choice tests were developed for testing the antifeedant activity shown by the organic fractions on adults, and 5th and 6th instar larvae of H. ligniperda. All the extracts tested elicited a decrease in the weight of unsexed H. ligniperda adults, and the effects were dose-dependent. Male beetle weight gain was reduced strongly by chloroform extracts and ethyl acetate elicited a weight increase of female and from the fifth and sixth instar larvae weight. Saponin extract elicited a reduction of the weight in male and female. Finally, the weight of both instar larvae was reduced by chloroform and saponin extract. C. parqui leaf extracts show a great potential for being used for controlling H. ligniperda and thus to diminish the use of harmful synthetic pesticide.

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“…Different species belonging to genus Cestrum were previously investigated for their chemical constituents, e.g., parquine, carboxyparquine and steroid. Glycosides were also identified in C. diurnum [3] , whereas saponins were identified in C. parqui [4,5] . In Chinese folk medicine, C. nocturnum used for the treatment of some health problems [6] .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical investigation and differential effects of Cestrum elegans isolated compounds as antimicrobial and virucidal against hepatitis A virus

et al. 2021

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A new steroidal saponin, named as (25R)-6α- [(β-D-glucopyranosyl) 2) was isolated from the flowers of Cestrum elegans. In addition, a known steroidal saponin (1), a flavonoid compound (3) along with a triterpene saponin (4) were isolated for the first time in genus Cestrum and identified based on their chromatographic properties, chemical and spectral data (HR-ESI-MS, 1 H, 13 C NMR, 1 H-1 H COSY, HSQC, and HMBC). The four compounds were evaluated for their antibacterial, antifungal and antiviral activities. The maximum non-toxic concentration (MNTC) on vero cell line was 1.56 µg/mL for all compounds. While, compound 1 and 3 showed antiviral activity of 34.3% and 25%, respectively.

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New cytotoxic steroidal saponins from Cestrum parqui

Cited by 19 publications

References 18 publications

Therapeutic properties and structural characterization of steroidal saponins: a review

Therapeutic properties and structural characterization of steroidal saponins: a review

Antifeedant Activities of Organic Fractions from Cestrum parqui Leaves on the Red-Haired Bark Beetle Hylurgus ligniperda

Phytochemical investigation and differential effects of Cestrum elegans isolated compounds as antimicrobial and virucidal against hepatitis A virus

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