New daily persistent headache: A systematic review and meta-analysis

Cheema, Sanjay; Mehta, Dwij; Ray, Jason C; Hutton, Elspeth; Matharu, Manjit

doi:10.1177/03331024231168089

Cited by 13 publications

(15 citation statements)

References 72 publications

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“…The characteristics of this large group of patients with NDPH are similar to those found in a recent meta-analysis of primary NDPH, and therefore it is likely to be a representative sample [ 4 ]. We confirm that NDPH is precipitated in approximately 40% of cases, most commonly following a flu-like viral illness, but also from a variety of other newly described events (see Table 2 ).…”

Section: Discussionmentioning

confidence: 74%

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Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache

et al. 2023

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Background It is unknown whether new daily persistent headache (NDPH) is a single disorder or heterogenous group of disorders, and whether it is a unique disorder from chronic migraine and chronic tension-type headache. We describe a large group of patients with primary NDPH, compare its phenotype to transformed chronic daily headache (T-CDH), and use cluster analysis to reveal potential sub-phenotypes in the NDPH group. Methods We performed a case–control study using prospectively collected clinical data in patients with primary NDPH and T-CDH (encompassing chronic migraine and chronic tension-type headache). We used logistic regression with propensity score matching to compare demographics, phenotype, comorbidities, and treatment responses between NDPH and T-CDH. We used K-means cluster analysis with Gower distance to identify sub-clusters in the NDPH group based on a combination of demographics, phenotype, and comorbidities. Results We identified 366 patients with NDPH and 696 with T-CDH who met inclusion criteria. Patients with NDPH were less likely to be female (62.6% vs. 73.3%, p < 0.001). Nausea, vomiting, photophobia, phonophobia, motion sensitivity, vertigo, and cranial autonomic symptoms were all significantly less frequent in NDPH than T-CDH (p value for all < 0.001). Acute treatments appeared less effective in NDPH than T-CDH, and medication overuse was less common (16% vs. 42%, p < 0.001). Response to most classes of oral preventive treatments was poor in both groups. The most effective treatment in NDPH was doselupin in 45.7% patients (95% CI 34.8–56.5%). Cluster analysis identified three subgroups of NDPH. Cluster 1 was older, had a high proportion of male patients, and less severe headaches. Cluster 2 was predominantly female, had severe headaches, and few associated symptoms. Cluster 3 was predominantly female with a high prevalence of migrainous symptoms and headache triggers. Conclusions Whilst there is overlap in the phenotype of NDPH and T-CDH, the differences in migrainous, cranial autonomic symptoms, and vulnerability to medication overuse suggest that they are not the same disorder. NDPH may be fractionated into three sub-phenotypes, which require further investigation.

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Section: Discussionmentioning

confidence: 74%

“…Despite the different tempo of onset, NDPH is often described in the literature as having a clinical phenotype resembling either CM or CTTH [ 4 , 5 ]. The pathophysiology of NDPH is poorly understood but some authors have argued that the similarity in phenotype suggests that primary NDPH is simply de-novo CM or CTTH [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache

et al. 2023

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“…NDPH, in itself, is a rare disease, and the post-covid-NDPH phenotype is untouched. A recent review by Cheema et al also conducted a systematic review of the main NDPH epidemiology, precipitants, phenotype, comorbidities, pathogenesis, therapy, and prognosis ( 12 ). An Italian multicentric case series to describe the characteristics of patients with NDPH following COVID infection has been recently conducted.…”

Section: Discussionmentioning

confidence: 99%

“…The appearance of NDPH may vary by nation or location for biological or cultural reasons. The same patient may be included or excluded from the diagnosis depending on which criteria were used in the research due to the shifting diagnostic criteria for NDPH ( 12 ). Although NDPH affects people of various ages, the majority of case studies featured individuals with a mean age between the twenties and the forties.…”

Section: Introductionmentioning

confidence: 99%

Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports

Dhiman,

Joshi,

Singh

et al. 2024

Front. Pain Res.

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Background and objectivesPost-acute COVID-19 syndrome or “long COVID” affects patients even after the recovery from Covid infection in various ways. Persistent headache or New Daily Persistent Headache (NDPH) is one of such symptoms. In this review, we will discuss about the case-reports of post covid-19 headache- NDPH phenotype both after and in the course of COVID-19 infection.MethodsCase reports/studies talked about patients having NDPH around the disease either immediately or late post COVID were included. Data was taken from the source and synthesised on a qualitative basis.ResultsLiterature search showed 3,538 articles, out of which 12 were screened as per the eligibility criteria and finally, 4 case reports on NDPH and Covid-19 were chosen for analysis from the database and by human search. All case reports justify the criteria for acceptability in quality for this systematic review.ConclusionNDPH in and around Covid 19 infection is something that is currently an ingenious debated topic in the scientific community. More case studies should be written and published on the same subject so that a large systematic review could be conducted.Trial Registration InformationThe review is registered in Prospero with no. Identifier (CRD42022354912).Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42022354912).

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“…Headaches, including migraine, tension-type headaches, and cluster headaches, are among the most prevalent neurological disorders associated with pain sensation, and significantly diminish patients' quality of life ( 1 ). Approximately 52% of the global population experience a headache disorder annually ( 2 ). Factors such as family history, smoking, alcohol consumption, male predominance, and head trauma are known to predict the occurrence of headaches ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses

Yang,

Dai,

et al. 2024

Front. Neurol.

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BackgroundGrowing evidence suggests that headache disorders and atopic dermatitis share similar pathological mechanisms and risk factors. The aim of this study was to assess the risk for headache disorders in patients with atopic dermatitis.MethodsWe systematically searched the PubMed and Embase databases from inception to December 1, 2023, for observational studies that examined risk of migraine in subjects with atopic dermatitis. Risk estimates from individual studies were pooled using random-effects models.ResultsTen studies with 12,717,747 subjects were included in the meta-analysis. Our results showed that patients with atopic dermatitis were associated with a higher risk of headache disorder (OR, 1.46, 95% CI = 1.36–1.56; P < 0.001; I2 = 98%) or migraine (OR, 1.32, 95% CI = 1.18–1.47; P < 0.001; I2 = 98.9%). Most of the results of the subgroup analyses were consistent with the overall results.ConclusionThe findings of this meta-analysis suggest that atopic dermatitis is a potential risk indicator for headache disorder or migraine. Further studies are still needed to verify our findings due to the substantial heterogeneity in our analyses.

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New daily persistent headache: A systematic review and meta-analysis

Cited by 13 publications

References 72 publications

Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache

Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache

Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports

Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses

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