New Derivatives of Lupeol and Their Biological Activity

Le, Hoang-Thuy-Tien; Chau, Quoc-Cuong; Duong, Thuc‐Huy; Tran, Quyen-Thien-Phuc; Pham, Nguyen-Kim-Tuyen; Nguyen, Thi-Hoai-Thu; Nguyen, Ngoc-Hong; Sichaem, Jirapast

doi:10.3390/m1306

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Both B. galpinii and C. caffum exhibited the presence of lupeol at a % area of 2.99 and 3.96, respectively, while M. obtusifolia and M. undata contained phytol at a % area of 2.80 and 1.78, respectively. Besides its known antioxidant activity, Lupeol and its derivatives were reported to possess enormous anticancer, wound-healing, and anti-inflammatory activities [ 67 , 68 , 69 ]. Elsewhere, phytol was found to possess a notable immunostumulant and antimicrobial activity [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

GC-ToF-MS Profiling and In Vitro Inhibitory Effects of Selected South African Plants against Important Mycotoxigenic Phytopathogens

Mariri,

Dikhoba,

Mongalo

et al. 2023

Life

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The harmful effects following the ingestion of mycotoxin-contaminated food include the induction of cancers, mutagenicity, immune suppression, and toxicities that target organs of the digestive, cardiovascular, and central nervous systems. Synthetic fungicides are generally associated with a high toxic residue in food and the development of excessive fungal resistance. This study aimed to determine the antifungal activities against mycotoxigenic fungi of selected South African plant leaves and potentially develop plant-derived bio-fungicides, and, furthermore, to explore the in vitro antioxidant activity and the phytochemical spectra of the compounds of the selected medicinal plant extracts. The extracts were tested for antifungal activity against phytopathogenic strains using a microdilution broth assay. Bauhinia galpinii extracts exhibited the lowest minimum inhibitory concentration (MIC) against C. cladospoides and P. haloterans at 24 h incubation periods. C. caffrum had good antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with 50% inhibitory concentration (IC50) values of 0.013 mg/mL while B. galpini had IC50 values of 0.053 against free radicals of 2,2′-azinobis (3-ethylbenzthiazoline-6-suphonic acid (ABTS). The antimycotoxigenic and antioxidant activity exerted by both B. galpinii and C. caffrum may well be attributed to high TPC. In the GC-ToF-MS analysis, all the selected medicinal plants exhibited the presence of Hexadecanoic acid at varying % areas, while both B. galpinii and C. caffum exhibited the presence of lupeol at % area 2.99 and 3.96, respectively. The compounds identified, particularly the ones with higher % area, may well explain the biological activity observed. Although the selected medicinal plants exhibited a notable biological activity, there is a need to explore the safety profiles of these plants, both in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

GC-ToF-MS Profiling and In Vitro Inhibitory Effects of Selected South African Plants against Important Mycotoxigenic Phytopathogens

Mariri,

Dikhoba,

Mongalo

et al. 2023

Life

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“…So far, flavonoids are extracted from natural plant resources through separation techniques [281,282]. Recently, much progress has been made through a synthetic chemistry approach to investigate the structure-activity of flavonoid moieties [283], to promote synthetic units that control a precise interaction site within the biological system [284,285], and to modify the flavonoid backbone to achieve new functionalities [286], paving the way toward the discovery of new drugs [287].…”

Section: Flavonoids As Nutraceuticals and Prebiotics For Human Healthmentioning

confidence: 99%

Flavonoids Are Intra- and Inter-Kingdom Modulator Signals

et al. 2022

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Flavonoids are a broad class of secondary metabolites with multifaceted functionalities for plant homeostasis and are involved in facing both biotic and abiotic stresses to sustain plant growth and health. Furthermore, they were discovered as mediators of plant networking with the surrounding environment, showing a surprising ability to perform as signaling compounds for a multitrophic inter-kingdom level of communication that influences the plant host at the phytobiome scale. Flavonoids orchestrate plant-neighboring plant allelopathic interactions, recruit beneficial bacteria and mycorrhizal fungi, counteract pathogen outbreak, influence soil microbiome and affect plant physiology to improve its resilience to fluctuating environmental conditions. This review focuses on the diversified spectrum of flavonoid functions in plants under a variety of stresses in the modulation of plant morphogenesis in response to environmental clues, as well as their role as inter-kingdom signaling molecules with micro- and macroorganisms. Regarding the latter, the review addresses flavonoids as key phytochemicals in the human diet, considering their abundance in fruits and edible plants. Recent evidence highlights their role as nutraceuticals, probiotics and as promising new drugs for the treatment of several pathologies.

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“…In the ninth paper, Dr. Diana Becerra, Dr. Juan-Carlos Castillo and colleagues from Universidad Pedagógica y Tecnológica de Colombia and Universidad de los Andes (Colombia) reported the synthesis of 2-oxo-2H-chromen-7-yl 4-chlorobenzoate obtained by O-acylation of 7-hydroxy-2H-chromen-2-one [9]. Eventually, in the tenth paper, lupeol extracted from Bombax ceiba was used by Dr. Thuc-Huy Duong from the Ho Chi Minh City University of Education (Vietnam), Dr. Jirapast Sichaem from Thammasat University (Thailand), and colleagues, as a starting material to produce semi-synthetic derivatives exhibiting α-glucosidase inhibitory activity [10].…”

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confidence: 99%