New derivatives of quinuclidine as potential antihypertensive agents

Collins, Lance L.; Elkin, Samuel

doi:10.1002/jps.2600561230

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Natural Product Scaffolds As Antimalarials1

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2019

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Cited by 3 publications

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“…Quinine has a diverse pharmacological portfolio. In additional to its antimalarial activity it has been found to possess anticholinergic, 15 antihypertensive, 16 hypoglycemic, 17 potassium channel blocker, 18 and skeletal muscle relaxant effects. 19 It is also used worldwide in tonic water as a flavoring agent.…”

Section: Natural Product Scaffolds As Antimalarialsmentioning

confidence: 99%

Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

et al. 2016

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Natural products have played a pivotal role in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds. Many of these natural products have served as template for the design and development of antimalarial drugs currently in the clinic or in the development phase. In this review, we will detail those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have reached the clinic.

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