New detection strategies through supercritical fluid chromatography

Novotný, Miloš V.

doi:10.1002/jhrc.1240090303

Cited by 35 publications

(11 citation statements)

References 46 publications

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“…Capillary supercritical fluid chromatography (SFC) has been recognized as the separation method of choice for compounds that are not easily amenable to either gas or liquid chromatographic analysis (1)(2)(3). The former is ultimately limited by the involatility of large compounds or thermal lability at the high temperatures required in gas chromatography (GC).…”

mentioning

confidence: 99%

Evaluation of a supercritical fluid chromatograph coupled to a surface-wave-sustained microwave-induced-plasma detector

Luffer¹,

Galante²,

David³

et al. 1988

Anal. Chem.

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confidence: 99%

Evaluation of a supercritical fluid chromatograph coupled to a surface-wave-sustained microwave-induced-plasma detector

Luffer¹,

Galante²,

David³

et al. 1988

Anal. Chem.

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“…by the limited number of theoretical plates that it can provide in a practical analysis time and by the unavailability of sensitive universal or element-selective detectors (1).…”

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confidence: 99%

Characterization of microwave-induced plasma as a detector for supercritical fluid chromatography

Galante¹,

Selby²,

Luffer³

et al. 1988

Anal. Chem.

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A microwave-induced plasma (MIP) sustained In helium Is evaluated as an element-selective detector for capillary supercritical fluid chromatography (SFC). The plasma source, a surface-mlcrowave-lnduced plasma (surfatron), Is described. Optimal plasma conditions Including viewing position, helium flow rate, and applied microwave power are discussed for sulfur emission In the near-infrared spectral region. In addition, the effects of two common mobile phases (C02 and N20) on plasma stability, sensitivity, and spectral background from 200 to 1100 nm are assessed. Although the plasma was evaluated principally for use with SFC, much of the discussion Is relevant to Its application as a gas chromatographic detector.Capillary gas chromatography (GC) and capillary liquid chromatography (LC) possess inherent liabilities that make them unsuitable for many types of separations. The former is ultimately restricted by the limited volatility and thermal lability of many organic compounds. The latter is restricted

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“…In the class of gas chromatography detectors, there has been notable success with the flame ionization detector (FID) for mass measurement of volatile and even semi-volatile analytes. [78][79][80] Such a detector is insensitive to supercritical carbon dioxide fluid, as well as to carbon dioxide fluids modified with water or formic acid. SRI Instruments (Torrance, CA) markets a compact stand-alone unit that is interfaced with a heated sample inlet line.…”

Section: Suitable Mass Detectors For Process Applications Involving Smentioning

confidence: 99%

Supercritical fluids in medical radioisotope processing and chemistry, Part I: technology, instrumentation and methodology

Ferrieri

2003

Labelled Comp Radiopharmac

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SummaryAlthough the last two decades has seen a keen interest in using supercritical fluids as media for material processing and chemical reactions owing to their unique physical properties, this technology has been underutilized in medical radioisotope processing and chemistry. The successful application of this technology necessitates not only having a sound knowledge of the physicochemical properties and phenomena occurring within such critical states of matter, but also a clear idea of the tools needed and means for applying them. These topics will be presented under the cover of two parts. Part I will address topics on the general background of supercritical fluid technology, equipment needed, whether for chemistry or separation, and basic techniques to access critical states of matter. Part II will follow in a subsequent volume and is meant to provide a description of applications with cited examples and potential areas for development. The hope is that sufficient interest is stimulated so as to encourage radiochemists to look to alternative technologies of this nature to

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New detection strategies through supercritical fluid chromatography

Abstract: SummaryThisarticle review st hecurrent statusand developmental trends in detection for supercritical fluid chromatography. The "GC-like" and "LC-like" detection techniques are treated separately, while the needs of structural identification techniques for SFC separations are emphasized.

Cited by 35 publications

References 46 publications

Evaluation of a supercritical fluid chromatograph coupled to a surface-wave-sustained microwave-induced-plasma detector

Evaluation of a supercritical fluid chromatograph coupled to a surface-wave-sustained microwave-induced-plasma detector

Characterization of microwave-induced plasma as a detector for supercritical fluid chromatography

Supercritical fluids in medical radioisotope processing and chemistry, Part I: technology, instrumentation and methodology

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