New developments in inhaler devices within pharmaceutical companies: A systematic review of the impact on clinical outcomes and patient preferences

Ninane, Vincent; Vandevoorde, Jan; Cataldo, Didier; Derom, Eric; Liistro, Giuseppe; Munghen, Evert; Peché, Rudi; Schlesser, Marc; Verleden, Geert M.; Vincken, Walter

doi:10.1016/j.rmed.2015.09.013

Cited by 22 publications

(26 citation statements)

References 42 publications

(44 reference statements)

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“…However, as the majority (40/44) of the studies included in the NMA were blinded, it is unlikely that these differences in inhaler type would be reflected in the results. Currently, while several studies have identified patient preferences between different inhaler types [53][54][55], there is limited evidence to demonstrate any differences in efficacy outcomes [56,57]. Further research is therefore required to inform optimal device design, improve compliance, reduce handling errors and, ultimately, improve outcomes.…”

Section: Discussionmentioning

confidence: 99%

A Network Meta-Analysis of Long-Acting Muscarinic Antagonist (LAMA) and Long-Acting β2-Agonist (LABA) Combinations in COPD

Sion

Huisman²,

Punekar

et al. 2017

Pulm Ther

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Section: Discussionmentioning

confidence: 99%

A Network Meta-Analysis of Long-Acting Muscarinic Antagonist (LAMA) and Long-Acting β2-Agonist (LABA) Combinations in COPD

Sion

Huisman²,

Punekar

et al. 2017

Pulm Ther

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“…Currently, there is limited data exploring the impact of the new 'easier to use' devices on inhaler technique and clinical outcomes in real life. There is a trend towards few inhaler technique errors [88,89] and patient satisfaction favoring the newer devices, however, real-life, long-term data are not as yet available, and there is a call for well-designed studies in the future [90]. Until that time, training patients in all the steps required to use these newer inhaler devices is recommended [3].…”

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confidence: 99%

Identifying Critical Errors: Addressing Inhaler Technique in the Context of Asthma Management

et al. 2018

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Medication use has always played a highly significant role in the overall management of asthma, with appropriate use being linked to good asthma control. However, while patients with asthma enjoy the 'luxury' of having medications delivered directly to the lungs via inhaler devices, with that comes the additional challenge of ensuring that inhaler devices are used correctly. Research and practice provides evidence to the challenges associated with inhaler use and the particular steps that patients perform incorrectly. While this problem is well documented, acknowledged and reported, little has changed in 40 years, and the proportion of patients using inhaler devices remains unacceptably high. This review focuses on aspects specific to the errors that patient's make, the significance of these errors, and the important considerations for health care practitioners in supporting patients in correctly using their inhalers. This review highlights the complexities associated with patient's making inhaler technique errors and highlights the opportunities that lie in future technological developments of inhaler devices. Now more than ever, in the era of precision medicine, it is important that we address inhaler technique use once and for all.Keywords: Asthma control; Critical errors; Health behavior; Health care practitioners; Inhaler devices; Maintenance; Mastery; Skills THE IMPORTANCE OF MEDICATION USE IN OUR UNDERSTANDING OF RESPIRATORY DISEASEAfter decades of research, practice, and perceived knowledge, we find ourselves at crossroads in our understanding and management of airway diseases, such as asthma [1]. While asthma is an obstructive airways disease, which Pulm Ther (2018) 4:1-12 https://doi.org/10.1007/s41030-018-0051-0 to our current knowledge can neither be prevented nor cured, it is a disease that fluctuates in severity and 'control', is exacerbated by varying triggers, and its course over an individual's lifetime is essentially unpredictable [1]. While the conversation about asthma and airways disease more broadly is not the focus of this review, it becomes particularly relevant in our consideration of the use of medications. It is critical, now more than ever, that we understand the role of medication use, as it can provide us with further understanding about respiratory disease more broadly [2]. Given that asthma management is reliant on the use of medications [3], ensuring that patients use their medications correctly has become more than just a practical matter; it is a complex and critical issue. Correct medication use has become a fundamental step in our exploration and understanding of disease traits [1,2]: with careful and more precise evaluation of patient's response to treatment becoming integral to our understanding of disease endotypes and our evolution towards precision medicine [1,2]. For this reason, if for no other, it is now more important than ever that we address inhaler use, especially our knowledge of critical errors, which can 'cloud' our understanding of treatment success. T...

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“…Both clinical efficacy and safety are essential properties when choosing inhaled medications (12). To reduce inhaler-related side effects, the ideal device should be easy to use, dose delivery should be independent of the inspiratory flow, and release of the aerosol should be slow and constant, favoring low oropharyngeal and high pulmonary deposition (13).…”

Section: Patient Safetymentioning

confidence: 99%

“…Several recent innovations have improved the efficacy and performance of inhaler devices. Along with technological progress, and ideally with a once-daily dosing, it is important for patients to acquire the ability to use devices properly (13). However, in an online survey applied to 245 COPD patients, fewer steps to operate the inhaler, confirmation that the dose had been taken correctly, and easy coordination of the breathing maneuver were considered more important to patients (37).…”

Section: Patient Preferencementioning

confidence: 99%

Dispositivos de inhalación para asma y EPOC: una revisión de la literatura

Rincon-Montaña¹,

Rosselli²

2019

rev. colomb. neumol.

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Las investigaciones recientes se han concentrado en el desarrollo de nuevos dispositivos de inhalación. La innovación ha mejorado los inhaladores de dosis medida, polvo seco o res- piración controlada y los nebulizadores. El objetivo de este estudio fue realizar una revisión narrativa de la literatura acerca de los diferentes dispositivos de inhalación que se encuen- tran disponibles en el mercado y su asociación con los desenlaces para asma y EPOC. Las principales preocupaciones han sido facilitar la administración del medicamento al paciente favoreciendo la farmacocinética, seguridad, preferencia del paciente, cumplimiento de la medicación, calidad de vida y costos. La adherencia a la medicación tiene una asociación po- sitiva con la preferencia del paciente y la facilidad de uso del dispositivo que administra los medicamentos para el control de la enfermedad. Una buena adherencia a los medicamentos puede reducir los episodios de exacerbación, mejorar la calidad de vida y reducir los costos de las enfermedades respiratorias.

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New developments in inhaler devices within pharmaceutical companies: A systematic review of the impact on clinical outcomes and patient preferences

Abstract: Future developments of inhaler devices should all require well-designed studies to demonstrate patient benefit.

Cited by 22 publications

References 42 publications

A Network Meta-Analysis of Long-Acting Muscarinic Antagonist (LAMA) and Long-Acting β2-Agonist (LABA) Combinations in COPD

A Network Meta-Analysis of Long-Acting Muscarinic Antagonist (LAMA) and Long-Acting β2-Agonist (LABA) Combinations in COPD

Identifying Critical Errors: Addressing Inhaler Technique in the Context of Asthma Management

Dispositivos de inhalación para asma y EPOC: una revisión de la literatura

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