2018
DOI: 10.1080/13543784.2019.1557634
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New developments in investigational HDAC inhibitors for the potential multimodal treatment of cachexia

Abstract: Introduction: Cachexia is a frequent feature of chronic diseases. This syndrome includes loss of body weight, depletion of skeletal muscle mass and altered metabolic homeostasis. Acceleration of protein and energy metabolism, impaired myogenesis and systemic inflammation contribute to cachexia. Its occurrence impinges on treatment tolerance as well as on patient quality of life, however, no effective therapy is still available. Areas covered in this review: This review will focus on the use of histone deacetyl… Show more

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Cited by 11 publications
(4 citation statements)
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“…There are currently 18 known human HDACs, which are grouped into four classes. Classes I, II, and IV HDACs are zinc‐dependent proteins, while Class III HDACs require NAD+ 24‐26 . HDACs have been found to play a role in muscle development, as well as muscle wasting and degeneration wasting 26 .…”
Section: Discussionmentioning
confidence: 99%
“…There are currently 18 known human HDACs, which are grouped into four classes. Classes I, II, and IV HDACs are zinc‐dependent proteins, while Class III HDACs require NAD+ 24‐26 . HDACs have been found to play a role in muscle development, as well as muscle wasting and degeneration wasting 26 .…”
Section: Discussionmentioning
confidence: 99%
“…HDAC1 is a component of the histone deacetylase complex. Histone acetyltransferases and deacetylases are critical enzymes that affect the expression of a variety of genes related to muscle wasting by modulating satellite cell activation and differentiation [7].…”
Section: Introductionmentioning
confidence: 99%
“…Other HDAC inhibitors (such as MS-275) prevent contractile dysfunction during skeletal muscle disuse and reduces the extent of fiber atrophy [28]. Another potential effect of HDAC inhibitors is that these compounds could behave as exercise mimicking agents (a well-known strategy against cachexia) [29]. Bearing all this in mind, the aim of the present investigation was to explore if the combination of formoterol and AR42 has any synergistic effect on cancer-related cachexia.…”
Section: Introductionmentioning
confidence: 99%