New Developments in Mast Cell Biology

Arthur, Greer; Bradding, Peter

doi:10.1016/j.chest.2016.06.009

Cited by 40 publications

(29 citation statements)

References 124 publications

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“…Mast cell secreted cytokines have a pivotal role in the pathogenesis of allergic disease and inflammation [23, 24]. Interleukin-13 (IL-13) and monocyte chemoattractant protein 1 (MCP-1) are two cytokines among those produced by human and mouse mast cells.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Mast Cell Toll-Like Receptor 3 Expression and Cytokines Release by Histamine

Xie¹,

Wang²,

Peng³

et al. 2018

Cell Physiol Biochem

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Background/Aims: As a major inflammatory molecule released from mast cell activation, histamine has been reported to regulate TLRs expression and cytokine production in inflammatory cells present in the microenvironment. In this study, we determined the ability of histamine to modulate TLRs expression and cytokine production in mast cells. Methods: HMC-1 and P815 cells were exposed to various concentrations of histamine in the presence or absence of histamine antagonist for 2, 6 or 16 h. The effect of histamine on the expression of TLR3 protein and mRNA was analyzed by flow cytometry、 RT-PCR and immunofluorescent microscopy. Furthermore, we also examined the effect of histamine on the secretion of MCP-1 and IL-13 from mast cells by ELISA. Results: The amplification of TLR3 mRNA and protein expression in mast cells was observed after incubation with histamine, which was accompanied by increasing secretion of IL-13 and MCP-1 via H1 receptor. The signaling pathways of PI3K/ Akt and Erk1/2/MAPK contributed to these induction effects. Conclusion: These results demonstrate that histamine up-regulates the expression of TLR3 and secretion of IL-13 and MCP-1 in mast cells, thus identifying a new mechanism for the histamine inducing allergic response.

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Section: Discussionmentioning

confidence: 99%

Modulation of Mast Cell Toll-Like Receptor 3 Expression and Cytokines Release by Histamine

Xie¹,

Wang²,

Peng³

et al. 2018

Cell Physiol Biochem

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“…Numerous stages of the MC life cycle have the potential for therapeutic intervention in allergic disorders (134). Targeting the progenitor recruitment offers an upstream checkpoint that could be used to limit tissue MC activity.…”

Section: Disorders In Which Mcs and Eosinophils Are Present And Likelmentioning

confidence: 99%

Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer

et al. 2017

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Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich. These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally, immunologically, biochemically, and pharmacologically. However, MCs and eosinophils play a pivotal role in several allergic disorders. In addition, these cells are involved in autoimmune disorders, cardiovascular diseases, and cancer. MCs are distributed throughout all normal human tissues, whereas eosinophils are present only in gastrointestinal tract, secondary lymphoid tissues, and adipose tissue, thymus, mammary gland, and uterus. However, in allergic disorders, MCs and eosinophils can form the “allergic effector unit.” Moreover, in several tumors, MCs and eosinophils can be found in close proximity. Therefore, it is likely that MCs have the capacity to modulate eosinophil functions and vice versa. For example, interleukin 5, stem cell factor, histamine, platelet-activating factor (PAF), prostaglandin D2 (PGD2), cysteinyl leukotrienes, and vascular endothelial growth factors (VEGFs), produced by activated MCs, can modulate eosinophil functions through the engagement of specific receptors. In contrast, eosinophil cationic proteins such as eosinophil cationic protein and major basic protein (MBP), nerve growth factor, and VEGFs released by activated eosinophils can modulate MC functions. These bidirectional interactions between MCs and eosinophils might be relevant not only in allergic diseases but also in several inflammatory and neoplastic disorders.

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“…It has been demonstrated that mast cells (MCs) serve an important role in innate and acquired immune responses (5,6), such that certain diseases are associated with changes in the number of MCs at affected sites (7,8). MCs are abundant at the borders of the external environment, including the intestinal mucosa where MCs function as sentinel cells during immune defense (9,10).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of methamphetamine on mast cell activation and cytokine/chemokine production stimulated by lipopolysaccharide in C57BL/6J mice

Geng

et al. 2018

Exp Ther Med

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Previous studies have demonstrated that methamphetamine (MA) influences host immunity; however, the effect of MA on lipopolysaccharide (LPS)-induced immune responses remains unknown. Mast cells (MCs) are considered to serve an important role in the innate and acquired immune response, but it remains unknown whether MA modulates MC activation and LPS-stimulated cytokine production. The present study aimed to investigate the effect of MA on LPS-induced MC activation and the production of MC-derived cytokines in mice. Markers for MC activation, including cluster of differentiation 117 and the type I high affinity immunoglobulin E receptor, were assessed in mouse intestines. Levels of MC-derived cytokines in the lungs and thymus were also examined. The results demonstrated that cytokines were produced in the bone marrow-derived mast cells (BMMCs) of mice. The present study demonstrated that MA suppressed the LPS-mediated MC activation in mouse intestines. MA also altered the release of MC cytokines in the lung and thymus following LPS stimulation. In addition, LPS-stimulated cytokines were decreased in the BMMCs of mice following treatment with MA. The present study demonstrated that MA may regulate LPS-stimulated MC activation and cytokine production.

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New Developments in Mast Cell Biology

Cited by 40 publications

References 124 publications

Modulation of Mast Cell Toll-Like Receptor 3 Expression and Cytokines Release by Histamine

Modulation of Mast Cell Toll-Like Receptor 3 Expression and Cytokines Release by Histamine

Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer

Inhibitory effects of methamphetamine on mast cell activation and cytokine/chemokine production stimulated by lipopolysaccharide in C57BL/6J mice

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