New developments in non-exosomal and exosomal ncRNAs in coronary artery disease

Li, Jingru; Wu, Xinyu; Ma, Haocheng; Sun, Guihu; Ding, Peng; Si, Lu; Zhang, Lijiao; Yang, Ping; Peng, Yunzhu; Fu, Jingyun; Wang, Luqiao

doi:10.2217/epi-2022-0201

Cited by 7 publications

(3 citation statements)

References 122 publications

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“…Accumulating studies have demonstrated that exosomal ncRNAs are associated with various diseases, including diabetes, coronary artery disease, cancers and infectious diseases (47)(48)(49). For instance, Lai et al reported that exosomal lncRNA SOX2 overlapping transcript (SOX2-OT) promoted ovarian cancer progression, and SOX2-OT, miR-181b-5p and stearoyl-CoA desaturase 1 may serve as potential targets for the treatment of ovarian cancer (50).…”

Section: The Functions Of Exosomal Ncrnasmentioning

confidence: 99%

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Wang

et al. 2023

Front. Immunol.

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Tuberculosis (TB) is a major infectious disease induced by Mycobacterium tuberculosis (M. tb) which causes the world’s dominant fatal bacterial contagious disease. Increasing studies have indicated that exosomes may be a novel option for the diagnosis and treatment of TB. Exosomes are nanovesicles (30-150 nm) containing lipids, proteins and non-coding RNAs (ncRNAs) released from various cells, and can transfer their cargos and communicate between cells. Furthermore, exosomal ncRNAs exhibit diagnosis potential in bacterial infections, including TB. Additionally, differential exosomal ncRNAs regulate the physiological and pathological functions of M. tb-infected cells and act as diagnostic markers for TB. This current review explored the potential biological roles and the diagnostic application prospects of exosomal ncRNAs, and included recent information on their pathogenic and therapeutic functions in TB.

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Section: The Functions Of Exosomal Ncrnasmentioning

confidence: 99%

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Wang

et al. 2023

Front. Immunol.

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“…Acute myocardial infarction (AMI), a subset of acute coronary syndrome, is a prevalent and serious disease affecting countless individuals across the globe. It is characterized by alarmingly high rates of morbidity, mortality, and recurrence, making it a major health concern worldwide [ 1 , 2 ]. The primary culprit behind AMI is the formation of acute thrombus, AMI occurs when atherosclerotic plaques rupture, causing a sudden blockage of blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis and Lipid Metabolism in Acute Myocardial Infarction

Wu,

Li,

Cheng

et al. 2024

Rev. Cardiovasc. Med.

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Acute myocardial infarction (AMI) is triggered by the blockage of coronary arteries, leading to restricted blood flow to the myocardium, which results in damage and cell death. While the traditional understanding of cell death primarily revolves around apoptosis, a new player in the game has emerged: ferroptosis. This novel form of cell death relies on iron and is propelled by reactive oxygen species (ROS). Lipid metabolism, an indispensable physiological process, plays a vital role in preserving cellular homeostasis. However, when this metabolic pathway is disrupted, the accumulation of excess waste increases, specifically lipid peroxides, which are strongly linked to the occurrence and progression of AMI. As a result, comprehending this complex interaction between ferroptosis and lipid metabolism could pave the way for new therapeutic approaches in tackling AMI.

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“…In addition to these, exosomes are reported to play a vital role in the transport of pathological components in diseases such as infectious diseases, neurological diseases, and CAD ( Feng et al, 2019 ). Interestingly, the pathogenic role of exosomes in CAD was reported to be involved in disease progression ( Li et al, 2022 ). Therefore, inhibiting the CAD-associated proteins that are being transported to other cells/tissue via exosomes will help to slow the progression of CAD.…”

Section: Introductionmentioning

confidence: 99%

Pharmacoscreening, molecular dynamics, and quantum mechanics of inermin from Panax ginseng: a crucial molecule inhibiting exosomal protein target associated with coronary artery disease progression

Wani

et al. 2023

PeerJ

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Background Exosomes, microvesicles, carry and release several vital molecules across cells, tissues, and organs. Epicardial adipose tissue exosomes are critical in the development and progression of coronary artery disease (CAD). It is hypothesized that exosomes may transport causative molecules from inflamed tissue and deliver to the target tissue and progress CAD. Thus, identifying and inhibiting the CAD-associated proteins that are being transported to other cells via exosomes will help slow the progression of CAD. Methods This study uses a systems biological approach that integrates differential gene expression in the CAD, exosomal cargo assessment, protein network construction, and functional enrichment to identify the crucial exosomal cargo protein target. Meanwhile, absorption, distribution, metabolism, and excretion (ADME) screening of Panax ginseng-derived compounds was conducted and then docked against the protein target to identify potential inhibitors and then subjected to molecular dynamics simulation (MDS) to understand the behavior of the protein-ligand complex till 100 nanoseconds. Finally, density functional theory (DFT) calculation was performed on the ligand with the highest affinity with the target. Results Through the systems biological approach, Mothers against decapentaplegic homolog 2 protein (SMAD2) was determined as a potential target that linked with PI3K-Akt signaling, Ubiquitin mediated proteolysis, and the focal adhesion pathway. Further, screening of 190 Panax ginseng compounds, 27 showed drug-likeness properties. Inermin, a phytochemical showed good docking with −5.02 kcal/mol and achieved stability confirmation with SMAD2 based on MDS when compared to the known CAD drugs. Additionally, DFT analysis of inermin showed high chemical activity that significantly contributes to effective target binding. Overall, our computational study suggests that inermin could act against SMAD2 and may aid in the management of CAD.

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New developments in non-exosomal and exosomal ncRNAs in coronary artery disease

Cited by 7 publications

References 122 publications

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Ferroptosis and Lipid Metabolism in Acute Myocardial Infarction

Pharmacoscreening, molecular dynamics, and quantum mechanics of inermin from Panax ginseng: a crucial molecule inhibiting exosomal protein target associated with coronary artery disease progression

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