New developments in polymer-controlled, bioinspired calcium phosphate mineralization from aqueous solution

Bleek, Katrin; Taubert, Andreas

doi:10.1016/j.actbio.2012.12.027

Cited by 172 publications

(153 citation statements)

References 332 publications

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“…Possibly, this is correlated to the inhomogeneous distribution of nitrate ions and/or ammonium nitrate. Such an observation is also consistent with previous examples of calcium phosphate/cellulose hybrid materials [30] and with many bioinspired calcium phosphate precipitates in general [5,6].…”

Section: Discussionsupporting

confidence: 80%

“…The detailed composition of the precipitates depends on the relative concentrations of the precursor salt solutions and the polymer concentration. Consistent with previous studies [5], higher polymer concentrations and lower precursor concentrations lead to a material that is closer to a "real" hybrid material, while inverse conditions lead to samples that are more closely related to the control samples. Moreover, the crystal phase selection (HAP vs. DCPD in the current study) is not determined by the chemistry of the polymer additive, but by the precursor concentrations and the pH changes occurring during the mineralization process ( Figure 7); this observation is also consistent with literature [5,6].…”

Section: Discussionsupporting

confidence: 77%

“…The polymers have pK a values of 4.0 (carboxylic acid group) and 8.6 to 9.7 (amino group). or drug or gene delivery [5,[36][37][38][39]. As a result, although the amounts of polymeric additive needed for an individual application are not very large, the overall need for a special polymer may still be rather large, considering that toothpastes and mouthwash products for dental protection are an ever growing market [40,41].…”

Section: Resultsmentioning

confidence: 99%

“…As a result, the development of biomineralization-inspired (bio)materials based on renewable resources and via sustainable processes is of ever growing importance. Interestingly, however, although a large number of publications on bioinspired mineralization of calcium phosphate is available (see refs [5,6] for extensive reviews of the field), the number of studies on mineralization additives based on renewable raw materials is still rather limited. Carbohydrates are particularly interesting for hybrid (bio)materials development because they are available in large amounts and numerous protocols for their chemical modification exist [7].…”

Section: Introductionmentioning

confidence: 99%

“…However, besides a few water-soluble cellulose derivatives that are available on a commercial scale [26], the number of specific and tailor-made additives for calcium phosphate precipitation is still rather limited. This is interesting because calcium phosphate mineralization control or delivery of (polymer stabilized) calcium phosphate nanoparticles are interesting for e.g., dental repair (remineralization), toothpastes, or drug or gene delivery [5,[36][37][38][39]. As a result, although the amounts of polymeric additive needed for an individual application are not very large, the overall need for a special polymer may still be rather large, considering that toothpastes and mouthwash products for dental protection are an ever growing market [40,41].…”

Section: Introductionmentioning

confidence: 99%

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Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization

et al. 2016

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Abstract:The effect of cellulose-based polyelectrolytes on biomimetic calcium phosphate mineralization is described. Three cellulose derivatives, a polyanion, a polycation, and a polyzwitterion were used as additives. Scanning electron microscopy, X-ray diffraction, IR and Raman spectroscopy show that, depending on the composition of the starting solution, hydroxyapatite or brushite precipitates form. Infrared and Raman spectroscopy also show that significant amounts of nitrate ions are incorporated in the precipitates. Energy dispersive X-ray spectroscopy shows that the Ca/P ratio varies throughout the samples and resembles that of other bioinspired calcium phosphate hybrid materials. Elemental analysis shows that the carbon (i.e., polymer) contents reach 10% in some samples, clearly illustrating the formation of a true hybrid material. Overall, the data indicate that a higher polymer concentration in the reaction mixture favors the formation of polymer-enriched materials, while lower polymer concentrations or high precursor concentrations favor the formation of products that are closely related to the control samples precipitated in the absence of polymer. The results thus highlight the potential of (water-soluble) cellulose derivatives for the synthesis and design of bioinspired and bio-based hybrid materials.

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Section: Discussionsupporting

confidence: 80%