New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

“…In contrast to the 15 marine compounds ( 160 – 174 ) affecting the nervous system with investigated mechanisms of action discussed above, for marine compounds 175 – 188 , only an IC 50 was reported and consolidated in Table 2, but their respective molecular mechanisms of action remained undetermined: asperterpenol A ( 175 ) [173]; cymatherelactone ( 176 ) [174]; dictyodendrin H ( 177 ) [175]; geranylphenazinediol ( 178 ) [176]; halomadurones C and D ( 179 , 180 ) [177]; lamellarin O ( 39 ) [53]; ircinianin lactams A ( 181 , 182 ) [178]; and polar steroids ( 183 – 188 ) [179]. …”

Synthetic Approach to Dictyodendrins: A Facile Synthesis of Pyrrolo[2,3‐c]carbazole, Pyrrolodibenzothiophene, and Benzo[e]indole

“…We anticipate our method to be applicable towards the total syntheses of pyrrolocarbazole natural products, dictyodendrins, [1,11] ningalins, [20] and other related natural products. The present protocol of a vinylic precursor as a two-carbon synthon was highly useful to construct the core units of biologically important heterocycles.…”

“…[11] Despite the above-mentioned multistep protocols, there remains a need for an efficient route to more readily access either the dictyodendrins or their core units. [11] Despite the above-mentioned multistep protocols, there remains a need for an efficient route to more readily access either the dictyodendrins or their core units.…”

“…[11] Despite the above-mentioned multistep protocols, there remains a need for an efficient route to more readily access either the dictyodendrins or their core units. The cyclization method was also successfully applied to the syntheses of pyrrolodibenzothiophene and benzo[e]indole derivatives.…”

Recent Accomplishments in the Total Synthesis of Natural Products Through C–H Functionalization Strategies

“…It is also important to underline that in March 2012, chemical analysis of a southern Australian marine sponge, an Ianthella sp., yielded dictyodendrins F-J as new examples of these rare types of marine alkaloids [47]. It is also important to underline that in March 2012, chemical analysis of a southern Australian marine sponge, an Ianthella sp., yielded dictyodendrins F-J as new examples of these rare types of marine alkaloids [47].…”