New Dihydroagarofuranoid Sesquiterpenes from Celastrus paniculatus

Abstract

The six new dihydro-b-agarofuranoid sesquiterpenes 1 -6 and three known compounds were isolated from the whole plant of Celastrus paniculatus. The structures including relative configurations were elucidated by means of spectroscopic analyses. Compounds 1 -6 were evaluated for cytotoxicity against a panel of three human-tumor cell lines.Introduction. 14] effects. In our preliminary cytotoxicity screening for the genus Celastrus in Taiwan, the whole plant extract of C. paniculatus showed in vitro activity. In this article, we report the isolation and structural elucidation of the six new sesquiterpenes 1 -6 1 ) and of three known compounds, including a dihydro-b-agarofuranoid sesquiterpene,

Natural β-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus

“…24 Compound 26 lacks the C-2 acetoxy group of 42, as is evidenced by the signals at δ H 1.48 and 1.87 (H-2) and δ C 22.4 (C-2) (Tables 2 and 3). The correlations between H-1 and H-4 and between H-8 and H-9/H-15a in the NOESY spectrum permitted the establishment of its relative configuration.…”

A Flavone Constituent from Myoporum bontioides Induces M-Phase Cell Cycle Arrest of MCF-7 Breast Cancer Cells

“…The chemical investigation also yielded eight known compounds, myoporone ( 2 ) [ 15 ], rhamnocitrin ( 3 ) [ 16 ], norartocarpetin ( 4 ) [ 17 ], 5,7,4′-trihydroxyflavone ( 5 ) [ 18 ], tricin ( 6 ) [ 19 ], diosmetin ( 7 ) [ 20 ], 3,3′-dimethoxyquercetin ( 8 ) [ 14 ], and β-sitosterol ( 9 ) [ 21 ], which were all identified based on the previously published spectroscopic data.…”

“…The structures of compounds 2 – 9 were identified using spectroscopic methods and were compared with literature data [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ].…”

Identification of a Triterpenoid as a Novel PPARγ Activator Derived from Formosan Plants

“…The analyses of spectra (Supporting information, Fig. S1–S20) identified the chemical name and structure of the seven compounds as 5β,19‐epoxy‐19‐methoxycucurbita‐6,23‐dien‐3β,25‐diol ( 1 ) (Kimura et al ., ), 3β,7β‐dihydroxy‐25‐methoxycucurbita‐5,23‐dien‐19‐al ( 2 ) (Chen et al ., ), 3β,7β,25‐trihydroxycucurbita‐5,23‐dien‐19‐al ( 3 ) (Chen et al ., ), Kuguacin J ( 4 ) (Chen et al ., ), Momordicine II ( 5 ) (Fatope et al ., ), lupeol ( 6 ) (Weng and Yen, ), and β‐sitosterol ( 7 ) (Weng and Yen, ).…”