New Dihydrophenanthrene and Phenyldihydroisocoumarin Constituents of Trema orientalis

Dijoux‐Franca, Marie‐Geneviève; Tchamo, D. Noungoué; Cherel, Bruno; Cussac, M.; Tsamo, Etienne; Mariotte, A.-M.

doi:10.1021/np000275s

Cited by 16 publications

(16 citation statements)

References 16 publications

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“…These results confirm the work done by several authors who have shown the presence of terpenoid and polyphenols in the polar extracts obtained from the leaves of the plant [21,[23][24][25][26][30][31][32][33][34][35].…”

Section: Fractionation Of Fraction Fgsupporting

confidence: 90%

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Bio-guided Fractionation of the Ethanolic Extract from Leaves of Trema orientalis Blume (Cannabaceae), a Presumed Antihypertensive Plant from Congo-Brazzaville

Clair

Célestine

Carreyre

et al. 2019

EJMP

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Hypertension is a risk factor for cardiovascular disease, which is currently a real public health problem. This disease affects about one billion people worldwide and is responsible for more than 70% of cardiovascular related deaths. Recently, the World Health Organization reported that of the hypertensive cases detected in Congo, only 7% were controlled. Today, there is no lifetime treatment and existing drugs are less accessible by the African population. To treat the disease, the Congolese population uses more the medicinal plants. However, the majority of compounds responsible for the biological activity of these plants are not known. In order to bring out Congolese plants with antihypertensive properties, we focus our interest on Trema orientalis Blume (Canabaceae). An ethanolic extract of the leaves of Trema orientalis was prepared after successive depletion of the organic solvents. Thereafter, a bio-guided fractionation on silica gel of the ethanol extract was carried out. Fractionation monitoring was done by TLC and the results of vasodilating activity measured. The fractions exhibiting the best biological activity allowed a second fractionation process to obtain five fractions which are characteristic of polyphenols, in particular flavonoids, and which exhibited good vasodilating activity on the isolated aorta of rats. Our future work will focus on the identification of these biologically active compounds.

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Section: Fractionation Of Fraction Fgsupporting

confidence: 90%

“…As a result, we focus our interest on Trema orientalis Blume (Cannabaceae), a plant with a variety of biological activities, including arterial antihypertensive activity. This plant is used in traditional Congolese medicine to decrease blood pressure [17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Bio-guided Fractionation of the Ethanolic Extract from Leaves of Trema orientalis Blume (Cannabaceae), a Presumed Antihypertensive Plant from Congo-Brazzaville

Clair

Célestine

Carreyre

et al. 2019

EJMP

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“…Similarly, hydrolyzable tannins such as ellagic acid, flavogallonic acid, punicalagin, and terchebulin isolated from stem bark of T. avicennioides showed in vitro antitrypanosomal activity with no cytotoxic effect on a mammalian cell line (Shuaibu et al 2008). Furthermore, all the hexane and methanol extracts of the leaves of T. orientalis showed great selectivity for T. brucei rhodesiense over L6 cells Phytochemical investigation of the trunk and root bark of T. orientalis afforded compounds such as xanthones, secoiridoids, ursane derivatives, triterpenes phytosteroids, dihydrophenanthrene, and phenyldihydroisocoumarin Dijoux-Franca et al 2001). Antitrypanosomal activity of xanthones isolated from the root bark of Garcinia livingstonei has been reported.…”

Section: Resultsmentioning

confidence: 99%

Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine

et al. 2011

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Human African trypanosomiasis is a neglected tropical disease with complex clinical presentation, diagnosis, and difficult treatment. The available drugs for the treatment of trypanosomiasis are old, expensive, and less effective, associated with severe adverse reactions and face the problem of drug resistance. This situation underlines the urgent need for the development of new, effective, cheap, and safe drugs for the treatment of trypanosomiasis. The search for new antitrypanosomal agents in this study is based on ethnomedicine. In vitro antitrypanosomal activity of 36 plant extracts from 10 plant species from Nigerian ethnomedicine was evaluated against bloodstream forms of Trypanosoma brucei rhodesiense STIB 900. Cytotoxic activity was determined against mammalian L6 cells. Alamar blue assay was used to measure the endpoint of both antitrypanosomal and toxicity assays. The ethyl acetate extract of leaves of Ocimum gratissimum Linn. (Labiatae) showed the highest antitrypanosomal activity (IC(50) of 2.08 ± 0.01 μg/ml) and a high selective index of 29. Furthermore, the hexane, ethyl acetate, or methanol extracts of Trema orientalis (L.) Blume (Ulmaceae), Pericopsis laxiflora (Benth. ex Baker) Meeuwen, Jatropha curcas Linn. (Euphorbiaceae), Terminalia catappa Linn. (Combretaceae), and Vitex doniana Sweet (Verbenaceae) displayed remarkable antitrypanosomal activity (IC(50) 2.1-17.2 μg/ml) with high selectivity indices (20-80) for trypanosomes. The antitrypanosomal activity of T. catappa and T. orientalis against T. brucei rhodesiense (STIB 900) is being reported for the first time in Nigerian ethnomedicine, and these plants could be a potential source of antitrypanosomal agents.

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“…[24] Chemical investigation of extracts from root bark of this plant has led to the isolation of compounds such as hexacosanoic acid, 3-O-ß-glucopyranosyl-ß-sitosterol, simiarenone, 3,4-dihydroxybenzoic acid, 2α, 3α, 23-trihydroxyurs-12-en-28-oic acid and ß-sitosterol. [20212526] Structures of some compounds are shown in Figure 1c.…”

Section: Major Phytochemical Constituentsmentioning

confidence: 99%

Trema orientalis Linn. Blume: A potential for prospecting for drugs for various uses

Adinortey¹,

Galyuon²,

Asamoah³

2013

Phcog Rev

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Medicinal plants are used by traditional practitioners to treat several ailments. Ethnomedicinal studies on Trema orientalis Linn. Blume (Ulmaceae) have shown that it is used in the treatment of diabetes mellitus, respiratory diseases, oliguria, and malaria. This article is aimed at providing comprehensive information on the medicinal uses, biology, phytochemical constituents, and pharmacological data available on T. orientalis. This has been done to explore its therapeutic potential for future research opportunities. This review was compiled with information obtained from databases such as Medline, Elsevier, Springer, Science Direct, Pubmed, Google Scholar, and a library search for articles published in peer-reviewed journals. Compounds present in the plant include tannins, saponins, flavanoids, triterpenes, phytosterols, and several constituents of xanthones. Some pharmacological research done on the plant has focused on, hypoglycemic activity, analgesic, anti-inflammatory activities, anti-plasmodial activity, diuretic activity, laxativity effect, anti-convulsant activity, anti-helmintic activity, anti-sickling effect, anti-oxidant, and anti-bacterial activity. This compilation strongly supports the view that T. orientalis has beneficial therapeutic properties, and indicates its potential as an effective herbal remedy for several diseases. The promising results from several research works could be further substantiated by clinical trials.

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New Dihydrophenanthrene and Phenyldihydroisocoumarin Constituents of Trema orientalis

Cited by 16 publications

References 16 publications

Bio-guided Fractionation of the Ethanolic Extract from Leaves of Trema orientalis Blume (Cannabaceae), a Presumed Antihypertensive Plant from Congo-Brazzaville

Bio-guided Fractionation of the Ethanolic Extract from Leaves of Trema orientalis Blume (Cannabaceae), a Presumed Antihypertensive Plant from Congo-Brazzaville

Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine

Trema orientalis Linn. Blume: A potential for prospecting for drugs for various uses

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