New diketopiperazine alkaloid and polyketides from marine-derived fungus Penicillium sp. TW58-16 with antibacterial activity against Helicobacter pylori

Tian, Danmei; Gou, Xiaoshuang; Jia, Jia; Wei, Jihua; Zheng, Mingxin; Ding, Wenjuan; Bi, Hongkai; Wu, Bin; Tang, Jinshan

doi:10.1016/j.fitote.2021.105095

Cited by 9 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…231) and polyketides 697 – 704 . 232 A culture of P. sumatraense resulted in the isolation of 3-hydroxybutyric acid and glycolic acid derivatives 705 – 709 , ( 706 a known synthetic but new NP) 233 and cultures of various other Penicillium strains yielded diketopiperazine alkaloid 710 and polyketides 711 and 712 , 234 further tanzawaic acids 713 – 726 ( 719 and 720 known terrestrial fungal metabolites but new MNPs), 235 citrinin dimers 727 – 730 (ref. 236) and meroterpenes 731 , and 732 .…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

Carroll,

Copp,

Grkovic

et al. 2024

Nat. Prod. Rep.

View full text Add to dashboard Cite

show abstract

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

Carroll,

Copp,

Grkovic

et al. 2024

Nat. Prod. Rep.

View full text Add to dashboard Cite

show abstract

“…Walterolactone E (153) (Figure 3) was isolated from the hydrothermal-vent-sediment-derived Penicillium sp. TW58-16 [62].…”

Section: Lactonesmentioning

confidence: 99%

“…Leptosphaerone D (190) (Figure 4) was isolated from the hydrothermal-vent-sediment-derived Penicillium sp. TW58-16 [62]. 15-O-methyl ML-236A (191) (Figure 4) was isolated from the deep-sea-sediment-derived P. solitum MCCC 3A00215 [69].…”

Section: Other Polyketidesmentioning

confidence: 99%

See 1 more Smart Citation

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

Lv,

Zeng

2024

Marine Drugs

View full text Add to dashboard Cite

Marine-derived Penicillium fungi are productive sources of structurally unique and diverse bioactive secondary metabolites, representing a hot topic in natural product research. This review describes structural diversity, bioactivities and statistical research of 452 new natural products from marine-derived Penicillium fungi covering 2021 to 2023. Sediments are the main sources of marine-derived Penicillium fungi for producing nearly 56% new natural products. Polyketides, alkaloids, and terpenoids displayed diverse biological activities and are the major contributors to antibacterial activity, cytotoxicity, anti-inflammatory and enzyme inhibitory capacities. Polyketides had higher proportions of new bioactive compounds in new compounds than other chemical classes. The characteristics of studies in recent years are presented.

show abstract

Anthranilic Acid Accumulation in Saccharomyces cerevisiae Induced by Expression of a Nonribosomal Peptide Synthetase Gene from Paecilomyces cinnamomeus BCC 9616

et al. 2022

View full text Add to dashboard Cite

Heterologous expression of nrps33, a nonribosomal peptide synthetase gene, from Paecilomyces cinnamomeus BCC 9616 in Saccharomyces cerevisiae unexpectedly resulted in the accumulation of anthranilic acid, an intermediate in tryptophan biosynthesis. Based on transcriptomic and real‐time quantitative polymerase chain reaction (RT‐qPCR) results, expression of nrps33 affected the transcription of tryptophan biosynthesis genes especially TRP1 which is also the selectable auxotrophic marker for the expression vector used in this work. The product of nrps33 could inhibit the activity of Trp4 involved in the conversion of anthranilate to N‐(5′‐phosphoribosyl)anthranilate and therefore caused the accumulation of anthranilic acid. This accumulation could in turn result in down‐regulation of downstream tryptophan biosynthesis genes. Anthranilic acid is typically produced by chemical synthesis and has been used as a substrate for synthesising bioactive compounds including commercial drugs; our results could provide a new biological platform for production of this compound.

show abstract

New diketopiperazine alkaloid and polyketides from marine-derived fungus Penicillium sp. TW58-16 with antibacterial activity against Helicobacter pylori

Cited by 9 publications

References 27 publications

Marine natural products

Marine natural products

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

Anthranilic Acid Accumulation in Saccharomyces cerevisiae Induced by Expression of a Nonribosomal Peptide Synthetase Gene from Paecilomyces cinnamomeus BCC 9616

Contact Info

Product

Resources

About