New Directions in Antibacterial Research

Chu, Daniel T. W.; Plattner, Jacob J.; Katz, Leonard

doi:10.1021/jm960294s

Cited by 294 publications

(156 citation statements)

References 167 publications

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“…7 MRSA is resistant to β-lactams, and often resistant to other antibacterial agent such as macrolides, tetracyclines, aminoglycosides, and fluoroquinolones. 8 Vancomycin is prescribed for the treatment of MRSA infections, 8 however, the emergence of vancomycin-resistant Staphylococcus aureus was reported. 9,10 Therefore, the treatment other than antibiotic therapy is demanded.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity Of Shin’iseihaito (Xinyiqingfeitang) And its Components Against Methicillin-Resistant Staphylococcus aureus

Konishi¹,

Minami²,

Makino³

2017

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Objective: Shin'iseihaito (xinyiqingfeitang in Chinese, SSHT), a formula in traditional Japanese Kampo medicine and Chinese medicine comprising nine crude drugs, Gypsum, Ophiopogon Tuber, Scutellaria Root (SR, root of Scutellaria baicalensis), Gardenia Fruit, Anemarrhena Rhizome, Lilium Bulb, Magnolia Flower, Loquat Leaf, and Cimicifuga Rhizome (CR, rhizome of Cimicifuga heracleifolia), is commonly used to treat sinusitis associated with purulent nasal discharge and reddish nasal mucosa. We evaluated anti-bacterial activity of SSHT extract on methicillin-resistant Staphylococcus aureus (MRSA), one cause of bacterial sinusitis. Materials and Methods: Sterile paper disks impregnated with SSHT extract, the combination of crude drugs composing SSHT according to the traditional pharmacological theory, or each component were placed on Mueller-Hinton agar plates inoculated with several strains of MRSA isolated from the patients. The diameter of inhibitory zone was measured after 18-24 h incubation. Results: SSHT extract showed antibacterial activity against 128/190 (66.8%) MRSA clinical isolates. The effect of the extract of SSHT without heat-clearing drugs (SSHT-HC) or without exterior-releasing drugs (SSHT-ER) were significantly lower than that of SSHT extract. Each water extract of SR, Loquat Leaf, Magnolia Flower and CR showed significant anti-MRSA activity, and SR extract exhibited the largest inhibitory zone. Conclusions: SSHT has antibacterial activity against MRSA clinical isolates, and SR mainly contributes to the antibacterial activity of SSHT against MRSA clinical isolates.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity Of Shin’iseihaito (Xinyiqingfeitang) And its Components Against Methicillin-Resistant Staphylococcus aureus

Konishi¹,

Minami²,

Makino³

2017

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“…Unfortunately, an increasing resistance of bacteria to various antimicrobials is a pandemic phenomenon, which severely threatens the therapeutic effectiveness of the macrolides as well. 5 Two of the commonest mechanisms of macrolide resistance are erm-encoded methylation of 23S rRNA and mef-encoded efflux. The methyltransferase encoded by the erm gene can modify the key nucleotide A2058 in domain V of 23S rRNA through methylation, which bears the main responsibility for the resistance to macrolide antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial activity of new 4″-O-carbamates of 11,12-cyclic carbonate erythromycin A 6,9-imino ether

et al. 2011

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A series of new 400 -O-carbamates of 11,12-cyclic carbonate erythromycin A 6,9-imino ether were synthesized and evaluated for their in vitro antibacterial activity. All the desired compounds demonstrated favorable activity (0.03 lg ml -1 ) against erythromycin-susceptible Streptococcus pneumoniae comparable to the references, exhibiting 133-fold higher activity than precursor 2 or 3. Similarly, all of the analogs exhibited improved activity against the erythromycin-resistant S. pneumoniae encoded by the erm gene and the erm and mef genes, showing 4-32-fold more effectiveness than erythromycin A.

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“…Amongst these micro-organisms are fungi which are ubiquitous in environment and are saprophytic or parasitic in nature. The impact of fungi on human health can be accessed by the data saying that invasive fungal infections IFIs are responsible for around 1.5 million deaths worldwide each year [1][2][3]. They being eukaryotic in nature are harder to kill as the targets unique to them are fewer in number.…”

Section: Introductionmentioning

confidence: 99%

ABC and MFS Transporters: A reason for Antifungal drug resistance

Neelabh¹,

Singh²

2018

Arch Biotechnol Biomed

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Fungi cause a variety of diseases and are diffi cult to treat owing to their eukaryotic nature resulting in dearth of antifungal targets at hand. This problem is further elevated many folds due to the resistance mechanisms of fungi through which they circumvent the antifungal drugs administered for therapeutic purposes. Fungi have a variety of strategies for obtaining these resistances, amongst them pivotal role is played by the ABC and MFS transporters. This article encompasses the important genes and their respective roles of both the classes of the transporters in different species of fungi.

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New Directions in Antibacterial Research

Cited by 294 publications

References 167 publications

Antibacterial Activity Of Shin’iseihaito (Xinyiqingfeitang) And its Components Against Methicillin-Resistant Staphylococcus aureus

Antibacterial Activity Of Shin’iseihaito (Xinyiqingfeitang) And its Components Against Methicillin-Resistant Staphylococcus aureus

Synthesis and antibacterial activity of new 4″-O-carbamates of 11,12-cyclic carbonate erythromycin A 6,9-imino ether

ABC and MFS Transporters: A reason for Antifungal drug resistance

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