New directions in the basic and translational biology of interleukin-27

Wojno, Elia D. Tait; Hunter, Christopher A.

doi:10.1016/j.it.2011.11.003

Cited by 102 publications

(94 citation statements)

References 107 publications

(141 reference statements)

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“…Further studies are required to identify the factors that are derived from curdlanstimulated DCs and induce ICOS upregulation in CD4 + T cells. Recently, IL-27, a cytokine produced primarily by APCs after stimulation by microbial products or inflammatory mediators, has been shown to promote the generation of IL-10-producing Tr1 cells (40). IL-27 has also been shown to induce c-Maf, IL-21, IL- …”

Section: Discussionmentioning

confidence: 99%

β-Glucan Curdlan Induces IL-10–Producing CD4+ T Cells and Inhibits Allergic Airway Inflammation

Kawashima

Hirose

Iwata

et al. 2012

The Journal of Immunology

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A number of studies have suggested a correlation between a decreased incidence in infectious diseases and an increased incidence of allergic diseases, including asthma. Although several pathogen-derived products have been shown to possess therapeutic potential for allergic diseases, it remains largely unknown whether β-glucan, a cell wall component of a variety of fungi, yeasts, and bacteria, has a regulatory potential for allergic diseases. In this study, we examined the effect of curdlan, a linear β-(1-3)-glucan, on the development of allergic airway inflammation. We found that i.p. injection of curdlan significantly inhibited Ag-induced eosinophil recruitment and Th2 cytokine production in the airways. The activation of CD4+ T cells in the presence of curdlan induced IL-10–producing CD4+ T cells with high levels of c-Maf expression. Curdlan-induced development of IL-10–producing CD4+ T cells required the presence of APCs and ICOS/ICOS ligand interaction. Curdlan-induced development of IL-10–producing CD4+ T cells also required intrinsic expression of STAT6. Furthermore, the transfer of Ag-specific CD4+ T cells that were stimulated in the presence of curdlan inhibited Ag-induced eosinophil recruitment into the airways. Taken together, these results suggest that curdlan is capable of inducing IL-10–producing CD4+ T cells and inhibiting the development of eosinohilic airway inflammation, underscoring the therapeutic potential of curdlan for allergic diseases.

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Section: Discussionmentioning

confidence: 99%

β-Glucan Curdlan Induces IL-10–Producing CD4+ T Cells and Inhibits Allergic Airway Inflammation

Kawashima

Hirose

Iwata

et al. 2012

The Journal of Immunology

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“…Negative control over Th17 differentiation is regulated through four distinct mechanisms: IL-27 and IFN-γ through STAT1 activation (9,46,51,70,71); IL-2 and IL-4 through STAT5 activation (72,73); IL-13 through stimulation of IL-10 production by Th17 cells, leading to IL-6 downregulation and thus diminished IL-17 production (74); loss of the inhibition of RORγt by Foxp3 when IL-6 is present (75,76). The balance between Foxp3 and RORγt is therefore a very important factor in the Th17/iTreg equilibrium.…”

Section: Th17 Subsetmentioning

confidence: 99%

The role of Th17 and Treg responses in the pathogenesis of RSV infection

et al. 2015

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“…The wide expression of IL-27R by immune cells (14,15) indicates that IL-27 may be involved in many important immune processes. Recent studies show that IL-27 can promote Th1 differentiation, inhibit Th17 differentiation, regulate the regulatory T cell population, and induce IL-10-producing T cells; thus, IL-27 plays both pathogenic and protective roles in given infection or autoimmune disease models (16)(17)(18)(19)(20)(21)(22)(23)(24).…”

mentioning

confidence: 99%

Critical Role of Dendritic Cell–Derived IL-27 in Antitumor Immunity through Regulating the Recruitment and Activation of NK and NKT Cells

Wei

Xia

Sun

et al. 2013

The Journal of Immunology

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Critical roles of IL-27 in autoimmune diseases and infections have been reported; however, the contribution of endogenous IL-27 to tumor progression remains elusive. In this study, by using IL-27p28 conditional knockout mice, we demonstrate that IL-27 is critical in protective immune response against methyl-cholanthrene–induced fibrosarcoma and transplanted B16 melanoma, and dendritic cells (DCs) are the primary source. DC-derived IL-27 is required for shaping tumor microenvironment by inducing CXCL-10 expression in myeloid-derived suppressor cells and regulating IL-12 production from DCs, which lead to the recruitment and activation of NK and NKT cells resulting in immunological control of tumors. Indeed, reconstitution of IL-27 or CXCL-10 in tumor site significantly inhibits tumor growth and restores the number and activation of NK and NKT cells. In summary, our study identifies a previous unknown critical role of DC-derived IL-27 in NK and NKT cell–dependent antitumor immunity through shaping tumor microenvironment, and sheds light on developing novel therapeutic approaches based on IL-27.

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New directions in the basic and translational biology of interleukin-27

Cited by 102 publications

References 107 publications

β-Glucan Curdlan Induces IL-10–Producing CD4+ T Cells and Inhibits Allergic Airway Inflammation

β-Glucan Curdlan Induces IL-10–Producing CD4+ T Cells and Inhibits Allergic Airway Inflammation

The role of Th17 and Treg responses in the pathogenesis of RSV infection

Critical Role of Dendritic Cell–Derived IL-27 in Antitumor Immunity through Regulating the Recruitment and Activation of NK and NKT Cells

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