In order to assess the usefulness of the SleepStrip (SS) in screening for obstructive sleep apneahypopnea syndrome (OSAHS) in Japanese settings, we measured its sensitivity and specificity against the reference standard diagnostic full-night polysomnography (FN-PSG) using a real-life timeline, and compared them to that of the simultaneously applied pulse oximeter (PO), a routinely used OSAHS screener in Japan. A total of 110 consecutive subjects with the symptoms of OSAHS underwent simultaneous SS and PO screening tests followed by a diagnostic FN-PSG within 7 weeks, a common time frame for accessing PSG in Japan. Data for 83 subjects were available for the final analysis. We analyzed both SS and PO output data as a standalone screening parameter, without combining it with other predictors for OSAHS. We obtained 71.9%, 68.3%, 57.1% and 63.2%, 61.0%, 39.3% sensitivities for SS and PO respectively, in order of mild, moderate, and severe cut-off points. The specificity values were 73.1%, 81.0%, and 87.3% for SS, while they were 92.3%, 100.0%, and 98.2% for PO in order of rising cut-off points. The SS demonstrated better screening performance with high compliance compared to the routinely used PO in our real-life timeline study; however, this performance is still lower than required to fully recommend SS as a large-scale standalone screener in the diagnostic pathway of OSAHS in Japan.