New Directions in the Treatment of Non-Small Cell Lung Cancer: An Overview

Edelman, Martin J.

doi:10.1634/theoncologist.6-suppl_1-1

The Oncologist

2001

DOI: 10.1634/theoncologist.6-suppl_1-1

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New Directions in the Treatment of Non-Small Cell Lung Cancer: An Overview

Martin J. Edelman

Abstract: Clearly, vinorelbine is an active agent which is well tolerated and suitable for use in the management of NSCLC. It is likely to play a greater role in the future.

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The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice

Press

Buckle

Beijnen

et al. 2005

Cancer Chemother Pharmacol

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This study shows that P-gp has little effect on the disposition and oral bioavailability of VRL. A substantial fraction of an oral dose of VRL is absorbed from the gut of wild-type mice. Consequently, first-pass metabolism is the most important factor for explaining the modest oral bioavailability, but the results with RTV suggest that cyp3a plays only a modest role in metabolic breakdown in mice. Apparently, other routes of metabolic elimination are more important. These results suggest that also in patients the oral bioavailability may not gain substantially from the co-administration of a potent P-gp and/or Cyp3a inhibitor.

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The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice

Press

Buckle

Beijnen

et al. 2005

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

show abstract

Challenging the platinum combinations in the chemotherapy of NSCLC

2002

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Treatment of lung cancer in the elderly. Part I: non-small cell lung cancer

et al. 2003

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New Directions in the Treatment of Non-Small Cell Lung Cancer: An Overview

Abstract: Clearly, vinorelbine is an active agent which is well tolerated and suitable for use in the management of NSCLC. It is likely to play a greater role in the future.

Cited by 3 publications

References 20 publications

The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice

The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice

Challenging the platinum combinations in the chemotherapy of NSCLC

Treatment of lung cancer in the elderly. Part I: non-small cell lung cancer

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