In this study, we evaluated solid sorbents for their ability to passively control indoor CO concentration in buildings or rooms with cyclic occupancy (eg, offices, bedrooms). Silica supported amines were identified as suitable candidates and systematically evaluated in the removal of CO from indoor air by equilibrium and dynamic techniques. In particular, sorbents with various amine loadings were synthesized using tetraethylenepentamine (TEPA), poly(ethyleneimine) (PEI) and a silane coupling agent 3-aminopropyltriethoxysilane (APS). TGA analysis indicates that TEPA impregnated silica not only displays a relatively high adsorption capacity when exposed to ppm level CO concentrations, but also is capable of desorbing the majority of CO by air flow (eg, by concentration gradient). In 10 L flow-through chamber experiments, TEPA-based sorbents reduced outlet CO by up to 5% at 50% RH and up to 93% of CO adsorbed over 8 hours was desorbed within 16 hours. In 8 m flow-through chamber experiments, 18 g of the sorbent powder spread over a 2 m area removed approximately 8% of CO injected. By extrapolating these results to real buildings, we estimate that meaningful reductions in the CO can be achieved, which may help reduce energy requirements for ventilation and/or improve air quality.