2008
DOI: 10.1080/14756360801906202
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New diterpenoid alkaloids fromAconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors

Abstract: Two new diterpenoid alkaloids, heterophyllinine-A (1) and heterophyllinine-B (2), along with two known alkaloids dihydroatisine (3) and lycoctonine (4) were isolated from the roots of Aconitum heterophyllum Wall. The structure of (1) and (2), were deduced on the basis of spectral data. Compounds 1-2 inhibited acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes in a concentration-dependent manner with percent inhibition ranging between 4.24% and 6.94 % and 79.1 % and 82.… Show more

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Cited by 38 publications
(13 citation statements)
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“…These compounds exhibited significant antibacterial activity [46] Two new diterpenoid alkaloids, heterophyllinine-A (1) and heterophyllinine-B (2), along with two known alkaloids, were isolated from the roots of A. heterophyllum Wall. The structures were deduced on the basis of spectral data [47] Pharmacological/ Biological…”
Section: Role Of Biotechnology In Conservationmentioning
confidence: 99%
See 1 more Smart Citation
“…These compounds exhibited significant antibacterial activity [46] Two new diterpenoid alkaloids, heterophyllinine-A (1) and heterophyllinine-B (2), along with two known alkaloids, were isolated from the roots of A. heterophyllum Wall. The structures were deduced on the basis of spectral data [47] Pharmacological/ Biological…”
Section: Role Of Biotechnology In Conservationmentioning
confidence: 99%
“…Therapeutic v/s toxic potential was derived on the basis of side ester chain in aconitine [23] Aconitine causes persistent activation of Na + channels in heart, skeletal muscles, CNS by blocking their inactivation [23,48,49] Crude methanolic extract (90%) of A. chasmanthum showed antibacterial and antifungal activity [50] Heterophyllinine-A and heterophyllinine-B inhibit BChe (butylcholinestrase) casing Alzheimer disease more specifically than AChe (acetylcholinestrase) causing muscle contraction [47] Molecular Twenty primers were screened for the genetic analysis of Aconitum and 14 were selected giving 51 polymorphic bands. Also flavanoid profiles of species and subspecies of Aconitum shows significant correlation with genetic study.…”
Section: Role Of Biotechnology In Conservationmentioning
confidence: 99%
“…PTZ induces convulsions by inhibiting the GABA pathway (Corda et al, 1990). Drugs protecting against seizures induced by PTZ, reduce T-type calcium currents (Murali et al, 2008) and are considered to be useful for control of myoclonic and absence seizures (Nisar et al, 2009). In the PTZ model, administration of root extract of BM (600, and 800 mg/kg, i.p.)…”
Section: Resultsmentioning
confidence: 99%
“…The PTZ test represents a valid model for human generalized myoclonic seizures and also generalized seizures of the petit-mal (absence)-type (Malawska & Scatturin, 2003). Drugs protecting against seizures induced by PTZ, reduce T-type calcium currents (Murali et al, 2008) and are considered to be useful for control of myoclonic and absence seizures (Nisar et al, 2009). Since PTZ is a potent GABAA receptors antagonist (Jalalpure et al, 2009) and solasodine is ineffective in this model, it is likely that solasodine might not act through this mechanism.…”
Section: Pharmaceutical Biologymentioning
confidence: 99%