New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

Hou, Bolin; Liu, Sushi; Huo, Ruiyun; Li, Yue-Qian; Ren, Jinwei; Wang, Wenzhao; Wei, Tao; Jiang, Xuejun; Yin, Wen‐Bing; Liu, Hongwei; Liu, Ling; Li, Erwei

doi:10.3390/md19070362

Cited by 17 publications

(11 citation statements)

References 32 publications

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“…(Hsl2–6). Compound 89 showed moderate α -glucosidase inhibitory activity (IC 50 , 741.5 ± 2.83 µM) [ 31 ]. Compounds xylarianes A ( 91 ) and B ( 92 ) were obtained from Xylaria sp.…”

Section: Structural and Biological Activity Studiesmentioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Chen,

Yu,

Chen

et al. 2024

JoF

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The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from Xylaria and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.

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“…(Hsl2–6). Compound 89 showed moderate α -glucosidase inhibitory activity (IC 50 , 741.5 ± 2.83 µM) [ 31 ]. Compounds xylarianes A ( 91 ) and B ( 92 ) were obtained from Xylaria sp.…”

Section: Structural and Biological Activity Studiesmentioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Chen,

Yu,

Chen

et al. 2024

JoF

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“…Two new diterpenoids, hypoxyterpoids A ( 79 ) and B ( 80 ), were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. Among them, compound 79 showed moderate α -glucosidase inhibitory activities with IC 50 values of 74.2 ± 2.8 µM [ 29 ]. Two new brominated diterpenes, namely, laurendecumtriol ( 81 ) and 11- O -deacetylpinnaterpene C ( 82 ), were isolated and identified from the marine red alga Laurencia decumbens [ 30 ].…”

Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

“…Meanwhile, another four new isocoumarin derivatives, hypoxymarins A–D ( 295 – 298 ), were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. Particularly, compound 297 exhibited DPPH-scavenging activity with an IC 50 value of 15.4 ± 0.2 μM [ 29 ].…”

Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

et al. 2023

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Marine natural products (MNPs) play an important role in the discovery and development of new drugs. The Beibu Gulf of South China Sea harbors four representative marine ecosystems, including coral reefs, mangroves, seaweed beds, and coastal wetlands, which are rich in underexplored marine biological resources that produce a plethora of diversified MNPs. In our ongoing efforts to discover novel and biologically active MNPs from the Beibu Gulf, we provide a systematic overview of the sources, chemical structures, and bioactive properties of a total of 477 new MNPs derived from the Beibu Gulf, citing 133 references and covering the literature from the first report in November 2003 up to September 2022. These reviewed MNPs were structurally classified into polyketides (43%), terpenoids (40%), nitrogen-containing compounds (12%), and glucosides (5%), which mainly originated from microorganisms (52%) and macroorganisms (48%). Notably, they were predominantly found with cytotoxic, antibacterial, and anti-inflammatory activities. This review will shed light on these untapped Beibu Gulf-derived MNPs as promising lead compounds for the development of new drugs.

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“…Labdane-type diterpenoids are one of the most abundant categories of secondary metabolites, which are discovered in plants [ 1 , 2 ], fungi [ 3 , 4 ], and marine organisms [ 5 , 6 ]. The labdane derivatives were isolated mainly from plant materials in families such as the gymnospers, as well as the Asteraceae, Lamiaceae, and Zingiberaceae [ 7 , 8 ], and sometimes they were discovered in actinomycetes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Labdane-Type Diterpenoids from Streptomyces griseorubens and Their Antimicrobial and Cytotoxic Activities

Heo,

Kang,

Yang

et al. 2024

IJMS

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Chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived actinomycete, Streptomyces griseorubens, resulted in the discovery of five new labdane-type diterpenoids: chlorolabdans A-C (1–3), epoxylabdans A and B (4 and 5), along with one known analog (6). The structures of the new compounds were determined by spectroscopic analysis (HR-ESIMS, 1D, and 2D NMR) and by comparing their experimental data with those in the literature. The new compounds were evaluated for their antimicrobial activity, and 2 displayed significant activity against Gram-positive bacteria, with minimum inhibitory concentration (MIC) values ranging from 4 to 8 µg/mL. Additionally, 1, 2, and 4 were tested for their cytotoxicity against seven blood cancer cell lines by CellTiter-Glo (CTG) assay and six solid cancer cell lines by sulforhodamine B (SRB) assay; 1, 2, and 4 exhibited cytotoxic activities against some blood cancer cell lines, with concentration causing 50% cell growth inhibition (IC50) values ranging from 1.2 to 22.5 µM.

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New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

Cited by 17 publications

References 32 publications

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

Labdane-Type Diterpenoids from Streptomyces griseorubens and Their Antimicrobial and Cytotoxic Activities

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