New drug–drug and drug–nutraceutical salts of anti-emetic drug domperidone: structural and physicochemical aspects of new salts

Abstract

The drug-drug multicomponent crystals (cocrystal/salt) in pharmaceutical products may boast the major challenges of Fixed-Dose combinations (FDC) in coming years. The challenges associated with FDC such as drug incompatibility, solubility...

Weak but Vital: The Role of Solvents in Crystal Packing and Coassembly for the Formation of Multicomponent Salt Solvates of Clozapine with Oxalic Acid

“…Generally, an API molecule can be incorporated into the crystal lattice with molecules of uncharged or charged selected coformers when a cocrystal or salt is formed, respectively . In the coming years, the multicomponent crystals (salt/cocrystal) may overcome the major challenge of fixed-dose combinations in pharmaceutical products . When preparing pharmaceutical multicomponent cocrystals by the solution method, recrystallization, spray-drying, or many other solvent-based sections and pharmaceutical industrial processing, API drugs may be exposed to different solvents or solvent vapors, and then, solvates could form.…”

“…6 In the coming years, the multicomponent crystals (salt/cocrystal) may overcome the major challenge of fixed-dose combinations in pharmaceutical products. 7 When preparing pharmaceutical multicomponent cocrystals by the solution method, recrystallization, spraydrying, or many other solvent-based sections and pharmaceutical industrial processing, API drugs may be exposed to different solvents or solvent vapors, and then, solvates could form. Sometimes, there may be some drug development problems or other significant influences on physicochemical properties if unexpected solvates form by accident.…”