New drug therapy: Augmentin

Human Milk Oligosaccharides (HMOs) Sensitize Group B Streptococcus to Clindamycin, Erythromycin, Gentamicin, and Minocycline on a Strain Specific Basis

“…Its formulation features amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. 8,9 In a recent series of studies, we assayed heterogeneous HMOs for antimicrobial and antibiofilm activity against Streptococcus agalactiae (Group B Streptococcus, GBS). 10,11 GBS is an important bacterial pathogen that can be transmitted from mother to child during labor and delivery and is a leading cause of neonatal morbidity and mortality.…”

“…This approach, which involves coadministration of two or more antibiotics with different modes of action or coadministration of an antibiotic and an adjuvant that potentiates antibiotic function, can improve efficacy and suppress resistance development. , The combination of ampicillin and gentamicin, for example, is a multiantibiotic therapy that serves as a front-line treatment for pediatric sepsis. − Conversely, augmentin is an example of an antibiotic and antibiotic adjuvant therapy. Its formulation features amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. , …”