New Drugs of Abuse in North America

Antibody-catalyzed anaerobic destruction of methamphetamine

“…These mAbs were then further examined for their ability to recognize substrates 2-5. Competition ELISA between BSA-7 and the panel of substrates (2)(3)(4)(5) revealed that a single mAb, YX1-40H10, could bind to (ϩ)-2 with an apparent binding constant,…”

“…1), is a serious global problem (1)(2)(3). Immunopharmacotherapy that utilizes antibody-based therapeutics is being studied as an innovative approach to controlling the abuse of these psychoactive agents (4,5).…”

Comprehensive Analysis of Emerging New Psychoactive Substances by Ion Mobility Spectrometry and Mass Spectrometry

“…These substances are in the same class as mescaline (peyote), which is a naturally occurring drug that produces hallucinogenic effects similar to lysergic acid diethylamide (LSD) [50]. A common route of phenethylamine administration is oral ingestion, while other routes of ingestion, including intravenous and intramuscular injections, insufflation, smoking, and rectal use have been also reported [51]. Although there is a limited amount of published scientific literature, most phenethylamines are known as serotonergic agonists acting on serotonin receptors (5-HT2) with hallucinogenic effects [46][47].…”

“…Some examples of tryptamines Listed as Schedule I drugs under the Controlled Substances Act, psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and its metabolite psilocin (4-OH N,Ndimethyltryptamine) are found in Psilocybe mushrooms [57]. Psilocybe mushrooms are also called 'magic mushrooms' because of their hallucinogenic properties [51].…”

“…Tryptamines are synthetic hallucinogenic indolealkylamines that are structurally similar to psilocybin, psilocin, and bufotenine [51]. Some examples of tryptamines Listed as Schedule I drugs under the Controlled Substances Act, psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and its metabolite psilocin (4-OH N,Ndimethyltryptamine) are found in Psilocybe mushrooms [57].…”