New electrophoretic protein zone in pregnancy

Antigenic Constituents in Pregnancy Plasma which are Undetectable in Normal Non-Pregnant Female or Male Plasma

“…Boyer [5], and Robinson et al [6] demonstrated that pregnancy serum contained one alkaline phosphatase which was not observed in serum of non-preg nant women. This phosphatase was distinct from the pregnancy alphaglobulin zone described by Afonso et al [4].…”

“…More extensive studies with plasma samples from patients with a variety of systemic diseases are obviously required, but it is clear, however, that none of the pregnancy-associated antigens described above represent the pregnancy associated alkaline phosphatase reported by others [5,6]. Whether one is related to the pregnancy alpha-globulin zone [3,4] remains to be determined. On the basis of their electropho retic mobilities, two of the four antigens demonstrated may be the same as those described by Hoffman el al.…”

“…Using the more highly resolving starch gel elec trophoresis, Smithies [3] and subsequently A fonso et al [4], described an «-globulin protein band in the serum of pregnant women, which was apparently not detected in non-pregnant females or males. Boyer [5], and Robinson et al [6] demonstrated that pregnancy serum contained one alkaline phosphatase which was not observed in serum of non-preg nant women.…”

Immunological Comparison of Various Human Pregnancy-Associated Plasma Proteins

“…The immunological 'reactions of identity' seen above with pregnancy plasma and specific antisera to the PZP [2,3,5,[15][16][17], «,-pregnoglobulin [9], SP3 [10], Xh [13,14,30], PAG [7], Pal [8], new serum «»-macroglobulin [11], and pregnancy-associated a2-globulin [12] were unequivocal, and were never associated with spur formation. These findings confirm and extend more limited observations of other investigators, e. g., the finding of identity between SP3, Xh and PZP by B o h n [10]; the identification of «2-pregnoglobulin with Xh, PAG, and Pal by B e r n e [31], of Xh with Pal [13], of Xh with pregnan cy zone by H o f m a n n et al [32], and of PAG with Pal by H o r n e et al [7].…”

“…Smithies [1] and Afonso and de Alvarez [2,3], as well as others [4][5][6] described a plasma protein which became detectable by zone elec trophoresis in women during pregnancy (pregnancy zone). Other investi gators have demonstrated a confusing number of plasma components during gestation which were not usually seen prior to pregnancy, using 1 These investigations were supported by a research grant from the National Institute of Child Health and Human Development (No.…”