New ent-Isopimarane Diterpene from Mangrove Excoecaria agallocha L.

Bioactivity of Excoecaria agallocha

“…Clinical trials carried out on this plant showed its potential as anti-HIV, anticancer, antibacterial and antiviral agent (Peter et al, 1999). Previous phytochemical studies on E. agallocha revealed the presence of diterpenoids (ISI database, 2008;Ji-Dong et al, 2007;Li et al, 2007;Wang et al, 2006Kang et al, 2005), triterpenoids (Zou et al, 2006), fl avonoid (Konishi et al, 2003) and phorbole esters (Ericson et al, 1995). As part of our continuing phytochemical and bioactivity studies on Bangladeshi medicinal plants and also in other parts of the world (Alam et al, 2008a,b;Ali et al, 2008;Datta et al, 2007Datta et al, , 2004Saha et al, 2007;Uddin et al, 2007aUddin et al, -c, 2006aUddin et al, ,b, 2005Uddin et al, , 2004Rouf et al, 2006;Haque et al, 2004;Rahman et al, 2004;Delazar et al, 2006;Shoeb et al, 2007;Auzi et al, 2007;Zamani et al, 2007;Razavi et al, 2008), we now report on the neuropharmacological and antibacterial activities, and acute toxicty of the ethanol extract of the bark of E. agallocha in laboratory rodents as well as brine shrimp toxicity.…”

Bioactive Pimarane‐Type Diterpenes from Marine Organisms

“…Marine-derived fungus Eutypella scoparia from the sediment of South China Sea, produced libertellenone A (16), 11-deoxydiaporthein A (23), diaporthein A (24), diaporthein B (26), isopimara-8(14), 15-diene (29), and scopararane B (30; Figure 3). [15] Diaporthein B (26) exhibited potent cytotoxic activities against SF-268 (human glioma cell line), MCF-7 (human breast adenocarcinoma cell line), and NCI-H460 (human non-small cell lung cancer cell line) with IC 50 values of 9.2, 4.4, and 9.9 lM, respectively.…”

A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

“…[822232425262728293031323334353637383940414243444546474849505152535455] The details of their names are given in Table 5. The chemical structures of some isolated compounds are given in Figure 2.…”

“…About 41 labdane-type diterpenes 1–41 were isolated from E. agallocha . [822232425262728293031323334] Two new bis seco-labdane diterpenes 17 and 18 were isolated from resinous woods. [26] Several seco-labdane diterpenes were also isolated from the same plant.…”

“…[222432353435363738] Roots yielded four isopimarane diterpenes 42–45,[2235] five isopimarane diterpenes 47–51 were isolated from stems and leaves,[3637] compounds 46 and 53–55 were isolated from woods,[2438] and compound 52 was isolated from the whole plant. [32] Two isopiramane diterpenes 53 and 54 contains a seven membered lactone moieties. [38]…”